Recognition of foreign or misplaced nucleic acids is one of the principal modes by which the
immune system detects pathogenic entities. When cytosolic DNA is sensed, a signal is …

Abstract Cyclic GMP-AMP (cGAMP) synthase (cGAS) senses misplaced genomic,
mitochondrial, and microbial double-stranded DNA (dsDNA) to synthesize 2′ 3′-cGAMP …

Double-stranded DNA (dsDNA) sensor cyclic-GMP-AMP synthase (cGAS) along with the
downstream stimulator of interferon genes (STING) acting as essential immune-surveillance …

Detection of microbial DNA is an evolutionarily conserved mechanism that alerts the host
immune system to mount a defense response to microbial infections. However, this detection …

The cGAS–STING signalling axis, comprising the synthase for the second messenger cyclic
GMP–AMP (cGAS) and the cyclic GMP–AMP receptor stimulator of interferon genes …

Ischemic stroke, a primary cause of disability and the second leading cause of mortality, has
emerged as an urgent public health issue. Growing evidence suggests that the Cyclic GMP …

Cytosolic nucleic acid sensors have a critical role in detecting endogenous nucleic acids to
initiate innate immune responses during microbial infections and/or cell death. Several …

Abstract cGAS senses microbial and host-derived double-stranded DNA in cytoplasm to
trigger cellular innate immune response in a STING-dependent manner; however, it remains …

Aging is associated with an increased incidence of autoimmune diseases, despite the
progressive decline of immune responses (immunosenescence). This apparent paradox can …

Brain aging and neurodegeneration are associated with prominent microglial reactivity and
activation of innate immune response pathways, commonly referred to as …