NK cell education: not an on-off switch but a tunable rheostat

P Brodin, K Kärre, P Höglund - Trends in immunology, 2009 - cell.com
Heterogeneity in the natural killer (NK) cell population is determined by variegated
expression of polygenic and polymorphic receptors and distinct phenotypes and functions of …

Tuning the threshold of natural killer cell responses

E Narni-Mancinelli, S Ugolini, E Vivier - Current opinion in immunology, 2013 - Elsevier
Natural killer cells are lymphocytes of the innate immune system that can kill an array of
tumor and infected cells and secrete cytokines that participate in the shaping of the adaptive …

Epigenetic regulation of NK cell differentiation and effector functions

F Cichocki, JS Miller, SK Anderson… - Frontiers in …, 2013 - frontiersin.org
Upon maturation, natural killer (NK) cells acquire effector functions and regulatory receptors.
New insights suggest a considerable functional heterogeneity and dynamic regulation of …

Natural killer cell education and the response to infection and cancer therapy: stay tuned

JE Boudreau, KC Hsu - Trends in immunology, 2018 - cell.com
The functional capacities of natural killer (NK) cells differ within and between individuals,
reflecting considerable genetic variation.'Licensing/arming','disarming', and 'tuning'are …

Diversification and functional specialization of human NK cell subsets

F Cichocki, H Schlums, J Theorell, B Tesi, JS Miller… - Natural Killer …, 2016 - Springer
Natural killer (NK) cells are lymphocytes that participate in different facets of immunity. They
can act as innate sentinels through recognition and eradication of infected or transformed …

NK cells regulating T cell responses: mechanisms and outcome

J Crouse, HC Xu, PA Lang, A Oxenius - Trends in immunology, 2015 - cell.com
Natural killer (NK) cells are important innate effectors in immunity. NK cells also have a role
in the regulation of the adaptive immune response, and have been shown, in different …

T cell regulation of natural killer cells

Y Kerdiles, S Ugolini, E Vivier - Journal of Experimental Medicine, 2013 - rupress.org
In light of their role in the immune response against tumors and viruses, natural killer (NK)
cells represent a promising target for immunotherapy. Before this target is reached, the …

Newtonian cell interactions shape natural killer cell education

JP Goodridge, B Önfelt, KJ Malmberg - Immunological reviews, 2015 - Wiley Online Library
Newton's third law of motion states that for every action on a physical object there is an
equal and opposite reaction. The dynamic change in functional potential of natural killer …

“Natural regulators”: NK cells as modulators of T cell immunity

IS Schuster, JD Coudert, CE Andoniou… - Frontiers in …, 2016 - frontiersin.org
Natural killer (NK) cells are known as frontline responders capable of rapidly mediating a
response upon encountering transformed or infected cells. Recent findings indicate that NK …

Developmental pathways that generate natural-killer-cell diversity in mice and humans

ND Huntington, CAJ Vosshenrich… - Nature Reviews …, 2007 - nature.com
Natural killer (NK) cells are large granular lymphocytes capable of producing inflammatory
cytokines and spontaneously killing malignant, infected or'stressed'cells. These NK-cell …