NK cell education: not an on-off switch but a tunable rheostat
Heterogeneity in the natural killer (NK) cell population is determined by variegated
expression of polygenic and polymorphic receptors and distinct phenotypes and functions of …
expression of polygenic and polymorphic receptors and distinct phenotypes and functions of …
Tuning the threshold of natural killer cell responses
Natural killer cells are lymphocytes of the innate immune system that can kill an array of
tumor and infected cells and secrete cytokines that participate in the shaping of the adaptive …
tumor and infected cells and secrete cytokines that participate in the shaping of the adaptive …
Epigenetic regulation of NK cell differentiation and effector functions
F Cichocki, JS Miller, SK Anderson… - Frontiers in …, 2013 - frontiersin.org
Upon maturation, natural killer (NK) cells acquire effector functions and regulatory receptors.
New insights suggest a considerable functional heterogeneity and dynamic regulation of …
New insights suggest a considerable functional heterogeneity and dynamic regulation of …
Natural killer cell education and the response to infection and cancer therapy: stay tuned
JE Boudreau, KC Hsu - Trends in immunology, 2018 - cell.com
The functional capacities of natural killer (NK) cells differ within and between individuals,
reflecting considerable genetic variation.'Licensing/arming','disarming', and 'tuning'are …
reflecting considerable genetic variation.'Licensing/arming','disarming', and 'tuning'are …
Diversification and functional specialization of human NK cell subsets
F Cichocki, H Schlums, J Theorell, B Tesi, JS Miller… - Natural Killer …, 2016 - Springer
Natural killer (NK) cells are lymphocytes that participate in different facets of immunity. They
can act as innate sentinels through recognition and eradication of infected or transformed …
can act as innate sentinels through recognition and eradication of infected or transformed …
NK cells regulating T cell responses: mechanisms and outcome
Natural killer (NK) cells are important innate effectors in immunity. NK cells also have a role
in the regulation of the adaptive immune response, and have been shown, in different …
in the regulation of the adaptive immune response, and have been shown, in different …
T cell regulation of natural killer cells
In light of their role in the immune response against tumors and viruses, natural killer (NK)
cells represent a promising target for immunotherapy. Before this target is reached, the …
cells represent a promising target for immunotherapy. Before this target is reached, the …
Newtonian cell interactions shape natural killer cell education
JP Goodridge, B Önfelt, KJ Malmberg - Immunological reviews, 2015 - Wiley Online Library
Newton's third law of motion states that for every action on a physical object there is an
equal and opposite reaction. The dynamic change in functional potential of natural killer …
equal and opposite reaction. The dynamic change in functional potential of natural killer …
“Natural regulators”: NK cells as modulators of T cell immunity
Natural killer (NK) cells are known as frontline responders capable of rapidly mediating a
response upon encountering transformed or infected cells. Recent findings indicate that NK …
response upon encountering transformed or infected cells. Recent findings indicate that NK …
Developmental pathways that generate natural-killer-cell diversity in mice and humans
ND Huntington, CAJ Vosshenrich… - Nature Reviews …, 2007 - nature.com
Natural killer (NK) cells are large granular lymphocytes capable of producing inflammatory
cytokines and spontaneously killing malignant, infected or'stressed'cells. These NK-cell …
cytokines and spontaneously killing malignant, infected or'stressed'cells. These NK-cell …