Erythropoietin (EPO) is the crucial cytokine regulator of red blood-cell production. Since the
discovery of EPO in 1985 and the isolation of its cognate receptor four years later, there has …

The process of erythropoiesis in the fetal liver and adult bone marrow is regulated by the
hormone erythropoietin (Epo), which is produced in the kidney at low levels under …

Erythropoietin (EPO) is a glycoprotein that is mainly produced in the adult kidney, and it was
initially highlighted for its action on the hematopoietic system. Moreover, EPO is also …

Since the isolation and purification of erythropoietin (EPO) in 1977, the essential role of EPO
for mature red blood cell production has been well established. The cloning of the EPO gene …

Events relayed via the single transmembrane receptor for erythropoietin (Epo) are essential
for the development of committed erythroid progenitor cells beyond the colony-forming unit …

More than 50 years of efforts to identify the major cytokine responsible for red blood cell
(RBC) production (erythropoiesis) led to the identification of erythropoietin (EPO) in 1977 …

RYTHROPOIETIN (EPO) is the principal growth factor E that promotes the viability,
proliferation, and differentiation of mammalian erythroid progenitor cells, functions that are …

A greatly expanded understanding of the biology of endogenous erythropoietin (EPO) has
emerged since the early 1990s. Originally viewed as the renal hormone dedicated to …

Erythropoietin (Epo) and its cognate receptor (EpoR) are required for maintaining adequate
levels of circulating erythrocytes during embryogenesis and adulthood. Here, we report the …

As essential mediators of red cell production, erythropoietin (EPO) and its cell surface
receptor (EPO receptor [EPOR]) have been intensely studied. Early investigations defined …