Scramblases play a pivotal role in facilitating bidirectional lipid transport across cell
membranes, thereby influencing lipid metabolism, membrane homeostasis, and cellular …

Mitochondria are double-membrane-bounded organelles that depend critically on
phospholipids supplied by the endoplasmic reticulum. These lipids must cross the outer …

Recent discoveries about functional mechanisms of proteins in the TMEM16 family of
phospholipid scramblases have illuminated the dual role of the membrane as both the …

Scramblases catalyze the movement of lipids between both leaflets of a bilayer. Whereas
the X-ray structure of the protein nhTMEM16 has previously revealed the architecture of a …

TMEM16F is a Ca2+-activated phospholipid scramblase in the TMEM16 family of membrane
proteins. Unlike other TMEM16s exhibiting a membrane-exposed hydrophilic groove that …

The transmembrane protein 16 (TMEM16) family of membrane proteins includes both lipid
scramblases and ion channels involved in olfaction, nociception, and blood coagulation …

From bacteria to mammals, different phospholipid species are segregated between the inner
and outer leaflets of the plasma membrane by ATP-dependent lipid transporters. Disruption …

Membranes in cells have defined distributions of lipids in each leaflet, controlled by lipid
scramblases and flip/floppases. However, for some intracellular membranes such as the …

Members of the TMEM16/ANO family of membrane proteins are Ca2+-activated
phospholipid scramblases and/or Cl− channels. A membrane-exposed hydrophilic groove in …

Glycerophospholipids are synthesized primarily in the cytosolic leaflet of the endoplasmic
reticulum (ER) membrane and must be equilibrated between bilayer leaflets to allow the ER …