FDA approval of several inhibitors of the VEGF pathway has enabled significant advances in
the therapy of cancer and neovascular age-related macular degeneration. However, similar …

Identification and characterization of VEGF as an important regulator of angiogenesis, and
FDA approval of the first anti-angiogenic drugs, has enabled significant advances in the …

Vascular endothelial growth factor (VEGF) is a key growth factor driving angiogenesis (ie the
formation of new blood vessels) in health and disease. Pharmacological blockade of VEGF …

Introduction: Angiogenesis was first proposed as a possible target for the treatment of
human cancer several decades ago. During recent years, the discovery of VEGF as the main …

The critical role of angiogenesis in tumour growth and metastasis is now well established in
the literature. Growing tumours stimulate neovascularisation through the secretion of pro …

Angiogenesis is defined as the physiological process by which new blood vessels develop
from pre-existing vessels; either by sprouting or intussusception. Inhibition of angiogenesis …

Angiogenesis is a crucial process for tissue development, repair, and tumor survival.
Vascular endothelial growth factor (VEGF) is a key driver secreted by cancer cells …

The establishment of a vascular supply is one of the earliest and most important events
occurring during embryonic development. Growth and maturation of a functional vascular …

Induction of angiogenesis represents one of the major hallmarks of cancer. The growth of
new vessels is crucial to provide malignant cells with an adequate supply of oxygen and …

Vascular endothelial growth factor (VEGF) dependent tumor angiogenesis is an essential
step for the initiation and promotion of tumor progression. The hypothesis that VEGF-driven …