A clinically and pathologically heterogeneous type of frontotemporal lobar degeneration has
abnormal tau pathology in neurons and glia (FTLD-tau). Familial FTLD-tau is usually due to …

The pathological distinctions between the various clinical and pathological manifestations of
frontotemporal lobar degeneration (FTLD) remain unclear. Using monoclonal antibodies …

In this report, we describe the clinical and neuropathological features of a case of familial
frontotemporal dementia (FTD), with onset at 58 years of age and disease duration of 10 …

Tauopathies are clinically, morphologically and biochemically heterogeneous
neurodegenerative diseases characterized by the deposition of abnormal tau protein in the …

Recently, mutations within the tau gene have been associated with some familial forms of
frontotemporal dementia. To investigate whether tau gene mutations are also associated …

Arnold Pick provided the first clinical description of fronwith FTDP-17 (Figure 1). The known
exonic mutations totemporal dementia in 1892, and since then this class are missense …

Pick's disease (PiD) is characterized by a pan-laminar frontotemporal cortical atrophy,
widespread degeneration of the white matter, chromatolytic neurons, and Pick bodies (PB) …

The study of rare, inherited forms of different diseases resulted in the discovery of gene
defects that cause inherited variants of the respective diseases. The defective genes were …

Frontotemporal dementia is a heterogeneous, often inherited disorder that typically presents
with the insidious onset of behavioral and personality changes. Two genetic loci have been …

Frontotemporal lobar degeneration (FTLD) encompasses a heterogeneous group of clinical
syndromes that include frontotemporal dementia (FTD), frontotemporal dementia with motor …