Background Tumor microenvironment (TME) is of great importance to regulate the initiation
and advance of cancer. The immune infiltration patterns of TME have been considered to …

Objective Immunotherapy directed at the tumor microenvironment is effective in the
treatment of head and neck squamous cell carcinoma (HNSCC). In contrast, there has been …

Background and Purpose Head and neck squamous carcinoma (HNSCC), characterized by
immunosuppression, is a group of highly heterogeneous cancers. Although immunotherapy …

Background Head and neck squamous cell carcinoma (HNSCC) is one of the few malignant
tumors that respond well to immunotherapy. We aimed to investigate the immune‐related …

Head and neck squamous cell carcinoma (HNSCC) is among the most destructive of tumors,
leading to considerable morbidity and mortality. Abnormal immune microenvironment is …

Purpose: Head and neck squamous cell carcinoma (HNSCC) has a high rate of local and
distant metastases. In tumor tissues, the interaction between tumor cells and the tumor …

The tumor microenvironment (TME) chiefly consists of tumor cells and tumor-infiltrating
immune cells admixed with the stromal component. A recent clinical trial has shown that the …

Introduction: The tumor microenvironment (TME) is crucial for the development of head and
neck squamous cell carcinoma (HNSCC). However, the correlation of the characteristics of …

Head and neck squamous cell carcinoma (HNSCC) is an immunosuppressive malignancy
accompanied by noted alterations in various immune cells and cytokines. Recognition of the …

The immune response within the tumor microenvironment plays a key role in tumorigenesis
and determines the clinical outcomes of head and neck squamous cell carcinoma (HNSCC) …