Adeno-associated virus serotype 4 (AAV4) and AAV5 have different tropisms compared to
AAV2 and to each other. We recently reported that α2-3 sialic acid is required for AAV5 …

Recombinant adeno-associated viruses (AAVs) are promising vectors in the field of gene
therapy. Different AAV serotypes display distinct tissue tropism, believed to be related to the …

Sialylated glycans serve as cell surface attachment factors for a broad range of pathogens.
We report an atypical example, where desialylation increases cell surface binding and …

Adeno-associated virus type 5 (AAV5) is distinct from other dependovirus serotypes based
on DNA hybridization and serological data. To better understand the biology of AAV5, we …

We have cloned and characterized the full-length genome of adeno-associated virus type 4
(AAV4). The genome of AAV4 is 4,767 nucleotides in length and contains an expanded p5 …

Early events, including the identification of the cellular receptor, have not yet been described
for adeno-associated virus (AAV) infection. In this study, the binding characteristics of AAV-2 …

The adeno-associated viruses (AAVs), which are being developed as gene delivery vectors,
display differential cell surface glycan binding and subsequent tissue tropisms. For AAV …

Adeno-associated virus (AAV) entry is determined by its interactions with specific surface
glycans and a proteinaceous receptor (s). Adeno-associated virus receptor (AAVR)(also …

Recombinant adeno-associated virus (rAAV) is a promising vector for gene therapy. Recent
isolations of novel AAV serotypes have led to significant advances by broadening the …

Adeno-associated viruses (AAVs) are small single-stranded DNA viruses that can package
and deliver nongenomic DNA for therapeutic gene delivery. AAV8, a liver-tropic vector, has …