Brain and muscle ARNT-like protein-1 (BMAL-1) is an important component of the cellular
circadian clock. Proteins such as epidermal (EGF) or nerve growth factor (NGF) affect the …

The circadian molecular clock is an internal time-keeping system, which regulates various
physiological processes through the generation of approximately 24-hour circadian rhythms …

The Drosophila shaggy gene product is a mammalian glycogen synthase kinase-3β (GSK-
3β) homologue that contributes to the circadian clock of the Drosophila through TIMELESS …

A central circadian clock located in the suprachiasmatic nucleus (SCN) of the mammalian
hypothalamus entrains peripheral clocks through both neural and humoral factors. Although …

Various physiological and behavioral processes exhibit circadian rhythmicity. These rhythms
are usually maintained by negative feedback loops of core clock genes, namely, CLOCK …

Circadian locomotor output cycles kaput (CLOCK) and brain and muscle aryl hydrocarbon
receptor nuclear translocator-like protein 1 (BMAL1) are master clock genes that regulate …

The integrated stress response (ISR) is activated in response to diverse stress stimuli to
maintain homeostasis in neurons. Central to this process is the phosphorylation of …

Specific neurons in the hypothalamus are regulated by peripheral hormones and nutrients to
maintain proper metabolic control. It is unclear if nutrients can directly control clock gene …

Background In mammals, the CLOCK/BMAL1 heterodimer is a key transcription factor
complex that drives the cyclic expression of clock-controlled genes involved in various …

Circadian clocks coordinate physiological, behavioral, and biochemical events with
predictable daily environmental changes by a self-sustained transcriptional feedback loop …