For many drugs, finding the balance between efficacy and toxicity requires monitoring their
concentrations in the patient's blood. Quantifying drug levels at the bedside or at home …

We introduce a general method to transform antibodies into ratiometric, bioluminescent
sensor proteins for the no‐wash quantification of analytes. Our approach is based on the …

Antibody detection is of fundamental importance in many diagnostic and bioanalytical
assays, yet current detection techniques tend to be laborious and/or expensive. We present …

Monitoring the levels of therapeutic antibodies in individual patients would allow patient-
specific dose optimization, with the potential for major therapeutic and financial benefits. Our …

Bioluminescent sensor proteins provide attractive tools for applications ranging from in vivo
imaging to point-of-care testing. Here we introduce a new class of ratiometric bioluminescent …

There is an increasing need for versatile yet sensitive labels, posed by the demands for low
detection in bioanalysis. Bioluminescent proteins have many desirable characteristics …

The ability to simultaneously monitor multiple analytes in, for example, a single microplate
well, is important for both basic research and clinical applications. In particular, for disease …

Therapeutic drug monitoring (TDM) is a fundamental tool when administering drugs that
have a limited dosage or high toxicity, which could endanger the lives of patients. To carry …

Heterogeneous immunoassays such as ELISA have become indispensable in modern
bioanalysis, yet translation into point-of-care assays is hindered by their dependence on …

Bioluminescence has been observed in nature since the dawn of time, but now, scientists
are harnessing it for analytical applications. Laura Rowe, Emre Dikici, and Sylvia Daunert of …