[HTML][HTML] Bacterial hydrophilins promote pathogen desiccation tolerance

ER Green, JN Fakhoury, AJ Monteith, H Pi… - Cell host & …, 2022 - cell.com
Acinetobacter baumannii is a leading cause of hospital-acquired infections, where
outbreaks are driven by its ability to persist on surfaces in a desiccated state. Here, we show …

[HTML][HTML] Desiccation tolerance in Acinetobacter baumannii is mediated by the two-component response regulator BfmR

JM Farrow III, G Wells, EC Pesci - PloS one, 2018 - journals.plos.org
For the opportunistic pathogen Acinetobacter baumannii, desiccation tolerance is thought to
contribute significantly to the persistence of these bacteria in the healthcare environment …

[HTML][HTML] Protein Aggregation is Associated with Acinetobacter baumannii Desiccation Tolerance

X Wang, CG Cole, CD DuPai, BW Davies - Microorganisms, 2020 - mdpi.com
Desiccation tolerance has been implicated as an important characteristic that potentiates the
spread of the bacterial pathogen Acinetobacter baumannii on dry surfaces. Here we explore …

Molecular mechanisms involved in the response to desiccation stress and persistence in Acinetobacter baumannii

CM Gayoso, J Mateos, JA Méndez… - Journal of proteome …, 2014 - ACS Publications
Desiccation tolerance contributes to the maintenance of bacterial populations in hospital
settings and may partly explain its propensity to cause outbreaks. Identification and relative …

Uncovering the mechanisms of Acinetobacter baumannii virulence

CM Harding, SW Hennon, MF Feldman - Nature Reviews Microbiology, 2018 - nature.com
Acinetobacter baumannii is a nosocomial pathogen that causes ventilator-associated as
well as bloodstream infections in critically ill patients, and the spread of multidrug-resistant …

CsrA-controlled proteins reveal new dimensions of Acinetobacter baumannii desiccation tolerance

Y Oda, MM Shapiro, NM Lewis, X Zhong… - Journal of …, 2022 - Am Soc Microbiol
Hospital environments are excellent reservoirs for the opportunistic pathogen Acinetobacter
baumannii in part because it is exceptionally tolerant to desiccation. We found that relative to …

Coping with low water activities and osmotic stress in Acinetobacter baumannii: significance, current status and perspectives

S Zeidler, V Müller - Environmental microbiology, 2019 - Wiley Online Library
Multidrug resistant (MDR) pathogens are one of the most pressing challenges of
contemporary health care. Acinetobacter baumannii takes a predominant position …

Lon Protease Has Multifaceted Biological Functions in Acinetobacter baumannii

C Ching, B Yang, C Onwubueke, D Lazinski… - Journal of …, 2019 - Am Soc Microbiol
Acinetobacter baumannii is a Gram-negative opportunistic pathogen that is known to survive
harsh environmental conditions and is a leading cause of hospital-acquired infections …

[HTML][HTML] ATP-dependent dynamic protein aggregation regulates bacterial dormancy depth critical for antibiotic tolerance

Y Pu, Y Li, X Jin, T Tian, Q Ma, Z Zhao, S Lin, Z Chen… - Molecular cell, 2019 - cell.com
Cell dormancy is a widespread mechanism used by bacteria to evade environmental
threats, including antibiotics. Here we monitored bacterial antibiotic tolerance and regrowth …

Rapid freezing enables aminoglycosides to eradicate bacterial persisters via enhancing mechanosensitive channel MscL-mediated antibiotic uptake

Y Zhao, B Lv, F Sun, J Liu, Y Wang, Y Gao, F Qi… - MBio, 2020 - Am Soc Microbiol
Bacterial persisters exhibit noninherited antibiotic tolerance and are linked to the
recalcitrance of bacterial infections. It is very urgent but also challenging to develop …