Amyloidosis is known to be caused by the deposition of amyloid fibrils into various biological
tissues; effective treatments for the disease are little established today. An infrared free …

Water plays a crucial role in the formation and destruction of biomolecular structures. The
mechanism for destroying biomolecular structures was thought to be an active breaking of …

A mid-infrared free-electron laser (FEL) is a linearly polarized, high-peak powered pulse
laser with tunable wavelength within the mid-infrared absorption region. It was recently …

A mid-infrared free-electron laser (FEL) is operated as a pulsed and linearly polarized laser
with tunable wavelengths within infrared region. Although the FEL can ablate soft tissues …

Amyloid fibrils are widely recognized as a cause of serious amyloidosis such as Alzheimer's
disease. Although dissociation of amyloid fibril aggregates is expected to lead to a decrease …

Amyloid fibril causes serious amyloidosis such as neurodegenerative diseases. The
structure is composed of rigid β-sheet stacking conformation which makes it hard to …

Amyloid fibrils are deposited in various tissues in the body, and are linked to the putative
causes of serious diseases such as amyloidosis. Although the conditions of the disease …

Recently, mid-infrared free-electron laser technology has been developed to dissociate
amyloid fibrils. Here, we present a theoretical framework for this type of experiment based on …

Neurodegenerative diseases are usually characterized by plaques made of well-ordered
aggregates of distinct amyloid proteins. Dissociating these very stable amyloid plaques is a …

Fibrous peptides such as amyloid fibrils have various roles in biological system, eg, as
causal factor of serious amyloidosis in human and as functional regulator of cell formation in …