The role of calcitonin gene–related peptide in peripheral and central pain mechanisms including migraine

S Iyengar, MH Ossipov, KW Johnson - Pain, 2017 - journals.lww.com
Calcitonin gene–related peptide (CGRP) is a 37-amino acid peptide found primarily in the C
and Aδ sensory fibers arising from the dorsal root and trigeminal ganglia, as well as the …

Calcitonin gene-related peptide (CGRP) receptor antagonists in the treatment of migraine

PL Durham, CV Vause - CNS drugs, 2010 - Springer
Based on preclinical and clinical studies, the neuropeptide calcitonin gene-related peptide
(CGRP) is proposed to play a central role in the underlying pathology of migraine. CGRP …

CGRP receptor antagonism and migraine

L Edvinsson, TW Ho - Neurotherapeutics, 2010 - Elsevier
Calcitonin gene-related peptide (CGRP) is expressed throughout the central and peripheral
nervous systems, consistent with control of vasodilatation, nociception, motor function …

Calcitonin gene-related peptide in migraine: intersection of peripheral inflammation and central modulation

AC Raddant, AF Russo - Expert reviews in molecular medicine, 2011 - cambridge.org
Over the past two decades, a convergence of basic and clinical evidence has established
the neuropeptide calcitonin-gene-related peptide (CGRP) as a key player in migraine …

Inhibition of calcitonin gene‐related peptide function: a promising strategy for treating migraine

PL Durham - Headache: The Journal of Head and Face Pain, 2008 - Wiley Online Library
The neuropeptide calcitonin gene‐related peptide (CGRP) is implicated in the underlying
pathology of migraine. Serum levels of CGRP, which are elevated during a migraine attack …

Antagonism of CGRP receptor: central and peripheral mechanisms and mediators in an animal model of chronic migraine

R Greco, C Demartini, M Francavilla, AM Zanaboni… - Cells, 2022 - mdpi.com
Calcitonin-gene-related peptide (CGRP) plays a key role in migraine pathophysiology and
more specifically in the mechanisms underlying peripheral and central sensitization. Here …

CGRP receptors in the control of pain and inflammation

S Benemei, P Nicoletti, JG Capone… - Current opinion in …, 2009 - Elsevier
Calcitonin gene related peptide (CGRP) has been proposed to contribute to pain
transmission and inflammation and for these reasons to the mechanism of migraine. CGRP …

Calcitonin gene‐related peptide (CGRP) and migraine

PL Durham - Headache: The Journal of Head and Face Pain, 2006 - Wiley Online Library
The neuropeptide calcitonin gene‐related peptide (CGRP) has long been postulated to play
an integral role in the pathophysiology of migraine. While clinical findings are consistent with …

Calcitonin gene-related peptide (CGRP): a new target for migraine

AF Russo - Annual review of pharmacology and toxicology, 2015 - annualreviews.org
Migraine is a neurological disorder that manifests as a debilitating headache associated
with altered sensory perception. The neuropeptide calcitonin gene-related peptide (CGRP) …

Role of CGRP in Migraine

L Edvinsson - Calcitonin Gene-Related Peptide (CGRP) Mechanisms …, 2019 - Springer
Migraine is a common neurological disorder that afflicts up to 15% of the adult population in
most countries, with predominance in females. It is characterized by episodic, often disabling …