The role of calcitonin gene–related peptide in peripheral and central pain mechanisms including migraine
S Iyengar, MH Ossipov, KW Johnson - Pain, 2017 - journals.lww.com
Calcitonin gene–related peptide (CGRP) is a 37-amino acid peptide found primarily in the C
and Aδ sensory fibers arising from the dorsal root and trigeminal ganglia, as well as the …
and Aδ sensory fibers arising from the dorsal root and trigeminal ganglia, as well as the …
Calcitonin gene-related peptide (CGRP) receptor antagonists in the treatment of migraine
PL Durham, CV Vause - CNS drugs, 2010 - Springer
Based on preclinical and clinical studies, the neuropeptide calcitonin gene-related peptide
(CGRP) is proposed to play a central role in the underlying pathology of migraine. CGRP …
(CGRP) is proposed to play a central role in the underlying pathology of migraine. CGRP …
CGRP receptor antagonism and migraine
L Edvinsson, TW Ho - Neurotherapeutics, 2010 - Elsevier
Calcitonin gene-related peptide (CGRP) is expressed throughout the central and peripheral
nervous systems, consistent with control of vasodilatation, nociception, motor function …
nervous systems, consistent with control of vasodilatation, nociception, motor function …
Calcitonin gene-related peptide in migraine: intersection of peripheral inflammation and central modulation
AC Raddant, AF Russo - Expert reviews in molecular medicine, 2011 - cambridge.org
Over the past two decades, a convergence of basic and clinical evidence has established
the neuropeptide calcitonin-gene-related peptide (CGRP) as a key player in migraine …
the neuropeptide calcitonin-gene-related peptide (CGRP) as a key player in migraine …
Inhibition of calcitonin gene‐related peptide function: a promising strategy for treating migraine
PL Durham - Headache: The Journal of Head and Face Pain, 2008 - Wiley Online Library
The neuropeptide calcitonin gene‐related peptide (CGRP) is implicated in the underlying
pathology of migraine. Serum levels of CGRP, which are elevated during a migraine attack …
pathology of migraine. Serum levels of CGRP, which are elevated during a migraine attack …
Antagonism of CGRP receptor: central and peripheral mechanisms and mediators in an animal model of chronic migraine
R Greco, C Demartini, M Francavilla, AM Zanaboni… - Cells, 2022 - mdpi.com
Calcitonin-gene-related peptide (CGRP) plays a key role in migraine pathophysiology and
more specifically in the mechanisms underlying peripheral and central sensitization. Here …
more specifically in the mechanisms underlying peripheral and central sensitization. Here …
CGRP receptors in the control of pain and inflammation
Calcitonin gene related peptide (CGRP) has been proposed to contribute to pain
transmission and inflammation and for these reasons to the mechanism of migraine. CGRP …
transmission and inflammation and for these reasons to the mechanism of migraine. CGRP …
Calcitonin gene‐related peptide (CGRP) and migraine
PL Durham - Headache: The Journal of Head and Face Pain, 2006 - Wiley Online Library
The neuropeptide calcitonin gene‐related peptide (CGRP) has long been postulated to play
an integral role in the pathophysiology of migraine. While clinical findings are consistent with …
an integral role in the pathophysiology of migraine. While clinical findings are consistent with …
Calcitonin gene-related peptide (CGRP): a new target for migraine
AF Russo - Annual review of pharmacology and toxicology, 2015 - annualreviews.org
Migraine is a neurological disorder that manifests as a debilitating headache associated
with altered sensory perception. The neuropeptide calcitonin gene-related peptide (CGRP) …
with altered sensory perception. The neuropeptide calcitonin gene-related peptide (CGRP) …
Role of CGRP in Migraine
L Edvinsson - Calcitonin Gene-Related Peptide (CGRP) Mechanisms …, 2019 - Springer
Migraine is a common neurological disorder that afflicts up to 15% of the adult population in
most countries, with predominance in females. It is characterized by episodic, often disabling …
most countries, with predominance in females. It is characterized by episodic, often disabling …
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