Immune responses to pathogens are complex and not well understood in many diseases,
and this is especially true for infections by persistent pathogens. One mechanism that allows …

Following infection with Mycobacterium tuberculosis, the causative agent of tuberculosis
(TB), most human hosts are able to contain the infection and avoid progression to active TB …

Highlights•TB is a nonresolving inflammatory disease.•Inflammatory mediators are
intertwined in networks during TB.•The pattern of infected cell death affects inflammation in …

Many pathogens are able to manipulate the signaling pathways responsible for the
generation of host immune responses. Here we examine and model a respiratory infection …

The acute inflammatory response, triggered by a variety of biological or physical stresses on
an organism, is a delicate system of checks and balances that, although aimed at promoting …

The primary goal of this study was to determine how chronic exposure to Ag influences the
functionality of Mycobacterium tuberculosis-specific T cell responses. The frequency of IFN-γ …

Infection with Mycobacterium tuberculosis causes> 1.5 million deaths worldwide annually.
Innate immune cells are the first to encounter M. tuberculosis, and their response dictates …

Mycobacterium tuberculosis is an enormously successful human pathogen that can infect its
host for decades without causing clinical disease, only to reactivate when host immunity is …

Tuberculosis is still a major health problem in the world. Initial interactions between
Mycobacterium tuberculosis and the host mark the pathway of infection and the subsequent …

A major challenge in tuberculosis (TB) is to improve current vaccination and therapeutic
strategies and this requires a fine understanding of the mechanisms that mediate protection …