Pathogenesis of human systemic lupus erythematosus: a cellular perspective

VR Moulton, A Suarez-Fueyo, E Meidan, H Li… - Trends in molecular …, 2017 - cell.com
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease affecting multiple
organs. A complex interaction of genetics, environment, and hormones leads to immune …

Pathogenesis of human systemic lupus erythematosus: recent advances

JC Crispín, SNC Liossis, K Kis-Toth… - Trends in molecular …, 2010 - cell.com
Systemic lupus erythematosus (SLE) is an autoimmune disease with manifestations derived
from the involvement of multiple organs including the kidneys, joints, nervous system and …

New insights into the immunopathogenesis of systemic lupus erythematosus

GC Tsokos, MS Lo, PC Reis, KE Sullivan - Nature Reviews …, 2016 - nature.com
The aetiology of systemic lupus erythematosus (SLE) is multifactorial, and includes
contributions from the environment, stochastic factors, and genetic susceptibility. Great gains …

Disentangling the pathogenesis of systemic lupus erythematosus: close ties between immunological, genetic and environmental factors

H Sutanto, Y Yuliasih - Medicina, 2023 - mdpi.com
Systemic Lupus Erythematosus (SLE) is a systemic autoimmune disease that attacks various
organ systems with a variety of clinical implications, ranging from mild skin and mucosal …

The pathogenesis of systemic lupus erythematosus—an update

J Choi, ST Kim, J Craft - Current opinion in immunology, 2012 - Elsevier
Systemic lupus erythematosus (SLE, lupus) is characterized by a global loss of self-
tolerance with activation of autoreactive T and B cells leading to production of pathogenic …

Updating on the pathogenesis of systemic lupus erythematosus

R Gualtierotti, M Biggioggero, AE Penatti… - Autoimmunity reviews, 2010 - Elsevier
Systemic lupus erythematosus (SLE) is a multi-organ autoimmune disease whose
pathogenesis is multifactorial lying on genetic, environmental factors and on abnormalities …

T cell signaling abnormalities contribute to aberrant immune cell function and autoimmunity

VR Moulton, GC Tsokos - The Journal of clinical …, 2015 - Am Soc Clin Investig
Systemic lupus erythematosus (SLE) is a prototype systemic autoimmune disease that
results from a break in immune tolerance to self-antigens, leading to multi-organ destruction …

[HTML][HTML] Pathogenic inflammation and its therapeutic targeting in systemic lupus erythematosus

TA Gottschalk, E Tsantikos, ML Hibbs - Frontiers in immunology, 2015 - frontiersin.org
Systemic lupus erythematosus (SLE, lupus) is a highly complex and heterogeneous
autoimmune disease that most often afflicts women in their child-bearing years. It is …

Systemic lupus erythematosus: diagnosis and clinical management

A Fava, M Petri - Journal of autoimmunity, 2019 - Elsevier
Systemic lupus erythematosus (SLE) is a worldwide chronic autoimmune disease which
may affect every organ and tissue. Genetic predisposition, environmental triggers, and the …

[HTML][HTML] Aberrant T cell signaling and subsets in systemic lupus erythematosus

T Katsuyama, GC Tsokos, VR Moulton - Frontiers in immunology, 2018 - frontiersin.org
Systemic lupus erythematosus (SLE) is a chronic multi-organ debilitating autoimmune
disease, which mainly afflicts women in the reproductive years. A complex interaction of …