Drug-induced gastrointestinal toxicity (GIT) is a common treatment-emergent adverse event
that can negatively impact dosing, thereby limiting efficacy and treatment options for …

Currently, 9 out of 10 experimental drugs fail in clinical studies. This has caused a 40%
plunge in the number of drugs approved by the US Food and Drug Administration (FDA) …

Intestinal organoids derived from LGR5+ adult stem cells allow for long-term culturing, more
closely resemble human physiology than traditional intestinal models, like Caco-2, and have …

In the past decade, intestinal organoid technology has paved the way for reproducing tissue
or organ morphogenesis during intestinal physiological processes in vitro and studying the …

Drug-induced gastrointestinal toxicities (GITs) rank among the most common clinical side
effects. Preclinical efforts to reduce incidence are limited by inadequate predictivity of in vitro …

Human intestinal organoids are an ideal model system for studying gastrointestinal
physiology and immunopathology. Altered physiology and mucosal immune response are …

Induction of cytochrome P450 can cause drug-drug interactions and efficacy failure.
Induction risk in liver and gut is typically inferred from experiments with plated hepatocytes …

In vitro models, such as primary cells and continuous cell lines routinely used for evaluating
drug candidates, have limitations in their translational relevance to human diseases …

Recent advances in our understanding of the intestinal stem cell niche and the role of key
signaling pathways on cell growth and maintenance have allowed the development of fully …

Organoids, characterized by their high physiological attributes, effectively preserve the
genetic characteristics, physiological structure, and function of the simulated organs. Since …