The sine oculis homeobox (SIX) family of transcription factors as regulators of development and disease

JP Kumar - Cellular and Molecular Life Sciences, 2009 - Springer
The sine oculis homeobox (SIX) protein family is a group of evolutionarily conserved
transcription factors that are found in diverse organisms that range from flatworms to …

[HTML][HTML] Six9 (Optx2), a new member of the six gene family of transcription factors, is expressed at early stages of vertebrate ocular and pituitary development

J López-Rı́os, ME Gallardo, SR de Córdoba… - Mechanisms of …, 1999 - Elsevier
The Drosophila gene sine oculis (so) is a nuclear homeoprotein, which is required for eye
development. Several homologues of so have been found in vertebrates. We report here a …

[HTML][HTML] Molecular cloning and embryonic expression of Xenopus Six homeobox genes

H Ghanbari, HC Seo, A Fjose, AW Brändli - Mechanisms of development, 2001 - Elsevier
Six genes are vertebrate homologues of the homeobox-containing gene sine oculis, which
plays an essential role in controlling Drosophila compound eye development. Here we …

[HTML][HTML] Expression pattern of cSix3, a member of the Six/sine oculis family of transcription factors

P Bovolenta, A Mallamaci, L Puelles… - Mechanisms of …, 1998 - Elsevier
We describe the expression pattern of cSix3, a chick homologue of the murine Six3. cSix3
transcripts are expressed from presomitic stages in the most anterior portion of the neural …

Six1: a critical transcription factor in tumorigenesis

W Wu, Z Ren, P Li, D Yu, J Chen… - … journal of cancer, 2015 - Wiley Online Library
In the past two decades, many studies have shown that sine oculis homeobox 1 (Six1) is a
powerful regulator of organogenesis and disease, with important roles in tumorigenesis; …

[HTML][HTML] Expression of two zebrafish homologues of the murine Six3 gene demarcates the initial eye primordia

HC Seo, Ø Drivenes, S Ellingsen, A Fjose - Mechanisms of development, 1998 - Elsevier
The murine homeobox gene Six3 and its Drosophila homologue sine oculis both have
regulatory functions in eye development. We report the isolation and characterization of two …

[HTML][HTML] Sine oculis, a member of the SIX family of transcription factors, directs eye formation

B Weasner, C Salzer, JP Kumar - Developmental biology, 2007 - Elsevier
The initiation of eye formation in all seeing animals is controlled by a group of selector
genes that together forms the retinal determination cascade. In Drosophila, mice and …

[HTML][HTML] Cloning and expression of xSix3, the Xenopus homologue of murine Six3

X Zhou, T Hollemann, T Pieler, P Gruss - Mechanisms of Development, 2000 - Elsevier
The vertebrate Six family of transcription factor genes are homologues of the fruitfly gene
sine oculis (so). Human, murine, avian and fish (medaka, zebrafish) homologues have …

Genomic cloning and characterization of the human homeobox gene SIX6 reveals a cluster of SIX genes in chromosome 14 and associates SIX6 hemizygosity with …

ME Gallardo, J Lopez-Rios, I Fernaud-Espinosa… - Genomics, 1999 - Elsevier
The Drosophila gene sine oculis (so), a nuclear homeoprotein that is required for eye
development, has several homologues in vertebrates (the SIX gene family). Among them …

Six3 and Six6 activity is modulated by members of the groucho family

J López-Ríos, K Tessmar, F Loosli, J Wittbrodt… - 2003 - journals.biologists.com
Six3 and Six6 are two genes required for the specification and proliferation of the eye field in
vertebrate embryos, suggesting that they might be the functional counterparts of the …