Catalytic, stereoselective dihalogenation of alkenes: challenges and opportunities

AJ Cresswell, STC Eey… - Angewandte Chemie …, 2015 - Wiley Online Library
Although recent years have witnessed significant advances in the development of catalytic,
enantioselective halofunctionalizations of alkenes, the related dihalogenation of olefins to …

Enantioselective dihalogenation of alkenes

J Bock, S Guria, V Wedek… - Chemistry–A European …, 2021 - Wiley Online Library
The dihalogenation of alkenes is one of the classic reactions in organic chemistry and a
prime example of an electrophilic addition reaction. The often observed anti‐selectivity in …

Catalytic, asymmetric halofunctionalization of alkenes—a critical perspective

SE Denmark, WE Kuester… - Angewandte Chemie …, 2012 - Wiley Online Library
Despite the fact that halogenation of alkenes has been known for centuries, enantioselective
variants of this reaction have only recently been developed. In the past three years, catalytic …

Enantioselective anti-Dihalogenation of Electron-Deficient Olefin: A Triplet Halo-Radical Pylon Intermediate

D Zhang, M Pu, Z Liu, Y Zhou, Z Yang… - Journal of the …, 2023 - ACS Publications
The textbook alkene halogenation reaction establishes straightforward access to vicinal
dihaloalkanes. However, a robust catalytic method for dihalogenizing electron-deficient …

Catalytic enantioselective dihalogenation in total synthesis

ML Landry, NZ Burns - Accounts of chemical research, 2018 - ACS Publications
Conspectus To date, more than 5000 biogenic halogenated molecules have been
characterized. This number continues to increase as chemists explore chloride-and bromide …

Urea group-directed organocatalytic asymmetric versatile dihalogenation of alkenes and alkynes

S Wu, SH Xiang, S Li, WY Ding, L Zhang, PY Jiang… - Nature Catalysis, 2021 - nature.com
The textbook alkene halogenation reaction establishes straightforward access to vicinal
dihaloalkanes. However, robust catalytic methods to perform dihalogenation in a …

Recent advances in asymmetric intra-and intermolecular halofunctionalizations of alkenes

YA Cheng, WZ Yu, YY Yeung - Organic & Biomolecular Chemistry, 2014 - pubs.rsc.org
This review seeks to provide coverage on recent advances in catalytic enantioselective
halofunctionalization of alkenes. The aim is to give an overview of various reports …

New catalytic approaches towards the enantioselective halogenation of alkenes

U Hennecke - Chemistry–An Asian Journal, 2012 - Wiley Online Library
The addition of electrophilic reagents to the carbon–carbon double bond is one of the most
fundamental reactions in organic chemistry. Halogen electrophiles constitute probably the …

Catalytic enantioselective iodoetherification of oximes

CB Tripathi, S Mukherjee - Angewandte Chemie, 2013 - Wiley Online Library
Heterodifunctionalization of unactivated olefins continues to be an attractive and widely
utilized strategy for the generation of densely functionalized organic molecules. Electrophilic …

Catalytic, stereospecific syn-dichlorination of alkenes

AJ Cresswell, STC Eey, SE Denmark - Nature chemistry, 2015 - nature.com
As some of the oldest organic chemical reactions known, the ionic additions of elemental
halogens such as bromine and chlorine to alkenes are prototypical examples of …