Background: To perform a review describing the pharmacokinetic (PK) parameters and
covariates of interest of the eight first choice β-lactams (BL) antibiotics for treatment of severe …

Background: To perform a review describing the pharmacokinetic (PK) parameters and
covariates of interest of the eight first choice β-lactams (BL) antibiotics for treatment of severe …

As antimicrobial susceptibility of common bacterial pathogens decreases, ensuring optimal
dosing may preserve the use of older antibiotics in order to limit the spread of resistance to …

Abstract Background and Objective In neonates, β-Lactam antibiotics are almost exclusively
administered by intermittent infusion. However, continuous or prolonged infusion may be …

Background Pharmacokinetics (PK) are severely altered in critically ill patients due to
changes in volume of distribution (Vd) and/or drug clearance (Cl). This affects the target …

The aim of this study was to assess the pharmacokinetic (PK) exposure and clinical toxicity
for three beta-lactams: cefotaxime, piperacillin/tazobactam, and meropenem, depending on …

Intravenous beta-lactam antibiotics are the most prescribed antibiotic class in US
hospitalized patients of all ages; therefore, optimizing their dosing is crucial. Bactericidal …

Background: β-lactams remain the cornerstone of the empirical therapy to treat various
bacterial infections. This systematic review aimed to analyze the data describing the dosing …

Background: β-lactams are among the most frequently prescribed antibiotics for the
treatment of neonatal sepsis. Survival of extremely preterm neonates necessitates an …

Aims Beta‐lactam dose optimization in critical care is a current priority. We aimed to review
the pharmacokinetics (PK) of three commonly used beta‐lactams (amoxicillin±clavulanate …