Impact of Oxysterols in Age-Related Disorders and Strategies to Alleviate Adverse Effects

S Ghosh, I Ghzaiel, A Vejux, S Meaney, S Nag… - Implication of Oxysterols …, 2023 - Springer
Oxysterols or cholesterol oxidation products are a class of molecules with the sterol moiety,
derived from oxidative reaction of cholesterol through enzymatic and non-enzymatic …

Cytotoxic effects of oxysterols associated with human diseases: Induction of cell death (apoptosis and/or oncosis), oxidative and inflammatory activities, and …

A Vejux, G Lizard - Molecular aspects of medicine, 2009 - Elsevier
Oxysterols resulting from spontaneous or enzymatic oxidation of cholesterol are present in
numerous foodstuffs and have been identified at increased levels in the plasma and the …

Involvement of oxysterols in age-related diseases and ageing processes

A Zarrouk, A Vejux, J Mackrill, Y O'Callaghan… - Ageing research …, 2014 - Elsevier
Ageing is accompanied by increasing vulnerability to major pathologies (atherosclerosis,
Alzheimer's disease, age-related macular degeneration, cataract, and osteoporosis) which …

Oxysterols: A world to explore

A Otaegui-Arrazola, M Menendez-Carreño… - Food and chemical …, 2010 - Elsevier
Oxysterols (oxidized derivatives of cholesterol and phytosterols) can be generated in the
human organism through different oxidation processes, some requiring enzymes …

Free radical attack on cholesterol: oxysterols as markers of oxidative stress and as bioactive molecules

F Micheletta, L Iuliano - Immunology, Endocrine & Metabolic …, 2006 - ingentaconnect.com
Oxysterols are oxygenated derivatives of cholesterol with a very short life-time relative to
cholesterol. Oxysterols are present in nanomolar concentrations in biological fluids …

Therapeutic Applications of Oxysterols and Derivatives in Age-Related Diseases, Infectious and Inflammatory Diseases, and Cancers

M Ksila, I Ghzaiel, K Sassi, A Zarrouk, V Leoni… - Implication of Oxysterols …, 2023 - Springer
Oxysterols, resulting from the oxidation of cholesterol, are formed either by autoxidation,
enzymatically, or by both processes. These molecules, which are provided in more or less …

Oxysterols are potential physiological regulators of ageing

P de Medina, S Silvente-Poirot, M Poirot - Ageing Research Reviews, 2022 - Elsevier
Delaying and even reversing ageing is a major public health challenge with a tremendous
potential to postpone a plethora of diseases including cancer, metabolic syndromes and …

Dietary phytochemicals in the protection against oxysterol-induced damage

A Cilla, A Alegria, A Attanzio, G Garcia-Llatas… - Chemistry and physics …, 2017 - Elsevier
The intake of fruits and vegetables is associated with reduced incidence of many chronic
diseases. These foods contain phytochemicals that often possess antioxidant and free …

A comprehensive review on oxysterols and related diseases

A Samadi, S Sabuncuoglu, M Samadi… - Current medicinal …, 2021 - ingentaconnect.com
The present review aims to provide a complete and comprehensive summary of current
literature relevant to oxysterols and related diseases. Oxidation of cholesterol leads to the …

Oxysterols as Biomarkers of Aging and Disease

IHK Dias, H Shokr - Implication of Oxysterols and Phytosterols in Aging …, 2023 - Springer
Oxysterols derive from either enzymatic or non-enzymatic oxidation of cholesterol. Even
though they are produced as intermediates of bile acid synthesis pathway, they are …