Recent studies have implicated the hypocretin/orexinergic system in reward-seeking
behavior. Almorexant, a dual orexin/hypocretin R1 and R2 receptor antagonist, has proven …

Rationale Recent studies suggest that orexin/hypocretin is involved in drug reward and drug-
seeking behaviors, including ethanol self-administration. However, orexin's role in ethanol …

Work from our laboratory has shown that orexin (ORX; or hypocretin) neurons in the lateral
hypothalamus are involved in preference for morphine, cocaine, and food. Other groups …

Orexins are hypothalamic neuropeptides which bind to two G-protein-coupled receptors,
orexin-1 (OX1R) and orexin-2 (OX2R) receptor. While a role for OX1R has been established …

Although originally implicated in appetite and sleep/wakefulness, the hypothalamic orexin
(hypocretin) system has now been demonstrably linked with motivated behavior. This highly …

Abstract Orexins ('hypocretins') are peptides produced by neurons of the hypothalamus that
project to structures implicated in reward and emotion processing. Converging evidence …

Orexins (hypocretins) are hypothalamic neuropeptides that innervate the entire neuraxis,
including the prelimbic cortex and ventral tegmental area and have been implicated in …

One decade ago, our laboratory provided the first direct evidence linking orexin/hypocretin
signaling with drug seeking by showing that activation of these neurons promotes …

Rationale Previous studies have shown that orexin-1/hypocretin-1 receptors play a role in
self-administration and cue-induced reinstatement of food, drug, and ethanol seeking. In the …

The orexins (or hypocretins) are neuropeptide transmitters made exclusively in
hypothalamic neurons that have extensive CNS projections. Previous studies reported that …