The purpose of this study was to determine in vivo myocardial energy metabolism and
function in a nutritional model of type 2 diabetes. Wistar rats rendered insulin-resistant and …

The metabolic phenotype of hearts has been investigated using rodent models of type 2
diabetes which exhibit obesity and insulin resistance: db/db and ob/ob mice, and Zucker …

Objectives: The purpose of this study was to determine if myocardial fatty acid utilization
(MFAU) and myocardial fatty acid oxidation (MFAO) are increased in diabetic patients …

Background In vitro data suggest that changes in myocardial substrate metabolism may
contribute to impaired myocardial function in diabetic cardiomyopathy (DCM). The purpose …

Background—Cardiovascular disease is the leading cause of death among diabetic
patients, with alteration in myocardial substrate metabolism being a likely contributor. We …

Introduction It is generally accepted that diabetic hearts have an altered metabolic
phenotype, with enhanced fatty acid (FA) utilization. The over-utilization of FA by diabetic …

Aims Diet-induced obesity is associated with increased myocardial fatty acid (FA) utilization,
insulin resistance, and cardiac dysfunction. The study was designed to test the hypothesis …

Aims/hypothesis. Fatty acids are an important source of energy in the myocardium.
Abnormal myocardial fatty acid metabolism could contribute to the deterioration of cardiac …

Although insulin resistance is recognized as a potent and prevalent risk factor for coronary
heart disease, less is known as to whether insulin resistance causes an altered cardiac …

Patients with diabetes are at very high risk of hospitalization and death from heart failure.
Increased prevalence of coronary heart disease, hypertension, autonomic neuropathy, and …