This study aimed at combining the hen's egg test-chorioallantoic membrane (HET-CAM),
bovine corneal opacity and permeability (BCOP) test and histological examination of …

This study aimed at preparing and evaluating Span 60-based niosomes for ocular delivery
of naltrexone hydrochloride (NTX). Selected charged lipids [dicetyl phosphate (DCP) and …

Recent reports have demonstrated that topical and systemic application of naltrexone
markedly improves the characteristic signs of diabetic keratopathy; most notably, impaired …

Naltrexone hydrochloride (NTX) is a promising treatment for corneal disorders linked to
diabetes mellitus (diabetic keratopathy). However, NTX has a major stability problem due to …

Niosomes have been reported as a possible approach to improve the low corneal
penetration and bioavailability characteristics shown by conventional ophthalmic vehicles …

Niosomes are emerging drug delivery systems that maintain the drug targeting advantages
of liposomes, while overcoming the problems of low drug encapsulation and instabilities …

Orally administered acetazolamide has a limited use in glaucoma due to the systemic side
effects associated with its use. No topical formulation of acetazolamide is available, mainly …

The aim of this work was to develop niosomes for the ocular delivery of epalrestat, a drug
that inhibits the polyol pathway and protects diabetic eyes from damage linked to sorbitol …

This study aimed at investigating the roles of both Span® surfactant type (having a gel/liquid
transition temperature range from< 10 to 55° C), and cholesterol level on in vitro …

Introduction Niosomes have recently grabbed attention as one of the best tools for various
site-specific drug delivery systems, including ophthalmic drug delivery. Surfactants …