O processo de nocicepção pode ser caracterizado como uma sensação que é capturada e
transmitida por neurônios periféricos (nociceptores), sensação esta que pode se originar de …

Neurotrophins are a family of trophic factors well known for their effects on neuronal survival,
growth and neuronal differentiation. During the last decade, a large literature has shown in …

The neuropathic pain syndrome is complex. Current drugs to treat neuropathic pain,
including anticonvulsivants and antidepressants, fail in up to 40-50% of the patients, while in …

The neurotrophin nerve growth factor (NGF) has been implicated as a key mediator of
chronic pain. NGF binds the tropomysin receptor kinase A (TrkA) and p75, resulting in the …

Nerve growth factor (NGF) was identified originally as a survival factor for sensory and
sympathetic neurons in the developing nervous system. In adults, NGF is not required for …

There continues to be an unmet need for safe and effective pain medications. Opioids and
nonsteroidal anti-inflammatory drugs (NSAIDs) dominate the clinical landscape despite …

Background NGF signaling through TrkA triggers pathways involved in a wide range of
biological effects. Clinical trials targeting either NGF or TrkA are ongoing to treat various …

The TrkA-PathHunter cell-based assay was used in high-throughput screening (HTS) to
identify compounds that inhibit nerve growth factor (NGF)/TrkA signaling. The assay was …

Abstract Nerve Growth Factor (NGF) has been implicated as playing a significant role in the
generation and maintenance of the nociceptive pain associated with a variety of human …

Nerve growth factor (NGF) was first discovered approximately 60 years ago by Rita Levi‐
Montalcini as a protein that induces the growth of nerves. It is now known that NGF is also …