Crosstalk between Epigenetics and Metabolic Reprogramming in Metabolic Dysfunction-Associated Steatotic Liver Disease-Induced Hepatocellular Carcinoma: A …

A Li, R Wang, Y Zhao, P Zhao, J Yang - Metabolites, 2024 - mdpi.com
Epigenetic and metabolic reprogramming alterations are two important features of tumors,
and their reversible, spatial, and temporal regulation is a distinctive hallmark of …

Pharmacological therapy of metabolic dysfunction-associated steatotic liver disease-driven hepatocellular carcinoma

Y Wang, JS Fleishman, T Li, Y Li, Z Ren… - Frontiers in …, 2024 - frontiersin.org
In light of a global rise in the number of patients with type 2 diabetes mellitus (T2DM) and
obesity, non-alcoholic fatty liver disease (NAFLD), now known as metabolic dysfunction …

Phenotypes of Metabolic Dysfunction–Associated Steatotic Liver Disease–Associated Hepatocellular Carcinoma

J Rivera-Esteban, S Muñoz-Martínez, M Higuera… - Clinical …, 2024 - Elsevier
Hepatocellular carcinoma (HCC) typically develops as a consequence of liver cirrhosis, but
HCC epidemiology has evolved drastically in recent years. Metabolic dysfunction …

Metabolism-associated epigenetic and immunoepigenetic reprogramming in liver cancer

C Fan, S Kam, P Ramadori - Cancers, 2021 - mdpi.com
Simple Summary Liver cancer is one of the most frequently occurring cancer types and one
of the leading causes of cancer-related mortality globally. Despite of its constantly growing …

DNA and RNA Sequencing Recapitulated Aberrant Tumor Metabolism in Liver Cancer Cell Lines

Y Sun, X Tang, B Ye, K Ding - Journal of Hepatocellular Carcinoma, 2021 - Taylor & Francis
Aim Metabolic reprogramming has recently attracted extensive attention for understanding
cancer development. We aimed to demonstrate a genomic and transcriptomic landscape of …

A review of MASLD-related hepatocellular carcinoma: progress in pathogenesis, early detection, and therapeutic interventions

Y Ma, J Wang, W Xiao, X Fan - Frontiers in Medicine, 2024 - frontiersin.org
The incidence of metabolic dysfunction-associated steatotic liver disease (MASLD) is
continuously rising, evolving into a global health challenge. Concurrently, cases of …

MASLD-Related HCC—Update on Pathogenesis and Current Treatment Options

C Leyh, JD Coombes, HH Schmidt, A Canbay… - Journal of Personalized …, 2024 - mdpi.com
Hepatocellular carcinoma (HCC) is a common complication of chronic liver diseases and
remains a relevant cause of cancer-related mortality worldwide. The global prevalence of …

Metabolic reprogramming and its relationship to survival in hepatocellular carcinoma

Q Wang, Y Tan, T Jiang, X Wang, Q Li, Y Li, L Dong… - Cells, 2022 - mdpi.com
Hepatocarcinogenesis is frequently accompanied by substantial metabolic reprogramming
to maximize the growth and proliferation of cancer cells. In this study, we carried out a …

Unraveling the Sweet Secrets of HCC: Glucometabolic Rewiring in Hepatocellular Carcinoma

SA Bhat, Z Farooq, H Ismail… - … in Cancer Research …, 2023 - journals.sagepub.com
Hepatocellular carcinoma (HCC) is the primary form of liver cancer. It causes∼ 800 000
deaths per year, which is expected to increase due to increasing rates of obesity and …

Comprehensive profiling of lipid metabolic reprogramming expands precision medicine for hepatocellular carcinoma

Q Liu, X Zhang, J Qi, X Tian, E Dovjak, J Zhang… - Hepatology, 2024 - journals.lww.com
Hepatology Publish Ahead of Print DOI:10.1097/HEP.0000000000000962 Page 1
Comprehensive profiling of lipid metabolic reprogramming expands precision medicine for …