Leukocytes sense extracellular ATP, a danger-associated molecular pattern, released
during cellular stress and death, via activation of cell surface P2X and P2Y receptors. Here …

Tissues differentially secrete multiple colony stimulating factors under conditions of
homeostasis and inflammation, orientating recruited circulating monocytes to differentiate to …

Extracellular ATP is a signaling molecule exploited by the immune cells for both autocrine
regulation and paracrine communication. By performing live calcium imaging experiments …

Extracellular ATP and other nucleotides act through specific cell surface receptors and
regulate a wide variety of cellular responses in many cell types and tissues. In this study, we …

Monocytes and macrophages express a repertoire of cell surface P2 receptors for
adenosine 5′-triphosphate (ATP) a damage-associated molecular pattern molecule …

Extracellular ATP activates the P2X7 receptor, leading to inflammasome activation and
release of pro‐inflammatory cytokines in monocytes. However, a detailed analysis of P2X7 …

Immune cells of myeloid origin show robust expression of ATP-gated P2X7 receptors, two-
transmembrane ion channels permeable to Na+, K+, and Ca 2+. Receptor activation …

Adenosine triphosphate (ATP) is known to induce cell death in T lymphocytes at high
extracellular concentrations. CD4+ and CD8+ T lymphocytes have a differential response to …

Extracellular ATP causes apoptosis and/or necrosis of the hemopoietic lineage through the
activation of P2X 7 receptors. In this study, we investigated P2X 7 receptor-mediated cell …

The effects of low concentrations of extracellular ATP on cytosolic Ca2+, membrane
potential, and transcription of IL-6 were studied in monocyte-derived human macrophages …