Prostate cancer is a prevalent disease that is characterized by a presumably long latency
period and a moderate propensity to metastasize. Although a range of mechanisms have …

Impaired expression of connexins, the gap junction subunits that facilitate direct cell-cell
communication, have been implicated in prostate cancer growth. To elucidate the crucial …

Gap‐junction‐mediated intercellular communication (GJIC) is required for completion of
embryonic development, tissue homeostasis, and regulation of cell proliferation and death …

BACKGROUND Connexins have their traditional function as part of gap junction (GJ)
structures, but have recently been shown to have GJ‐independent roles. Although GJs and …

Tissue homeostasis is the result of a complex intercellular network controlling the behavior
of every cell for the survival of the whole organism. In mammalian tissues, cells do …

BACKGROUND Gap junctional communication (GJC) has been implicated in the control of
cell proliferation. Numerous cancer cells show a decrease or loss of GJC compared to their …

Over the past 50 years, increasing experimental evidences have established that connexins
(Cxs) and gap junctional intercellular communication (GJIC) ensure an important role in both …

Gap junctions, composed of connexins, provide a pathway of direct intercellular
communication for the diffusion of small molecules between cells. Evidence suggests that …

Purpose: Gap junctions composed of connexin proteins have an essential role in
intercellular communication and differentiation. Dysregulation of connexin expression is …

This review focuses on connexins and nexus or gap junctions in the genesis, progression,
and therapy of carcinomas of the human urinary tract. Some decades ago, the idea was born …