Alkaloid binding to opium poppy major latex proteins triggers structural modification and functional aggregation

N Ozber, SC Carr, JS Morris, S Liang… - Nature …, 2022 - nature.com
Opium poppy accumulates copious amounts of several benzylisoquinoline alkaloids
including morphine, noscapine, and papaverine, in the specialized cytoplasm of laticifers …

A tale of three cell types: alkaloid biosynthesis is localized to sieve elements in opium poppy

DA Bird, VR Franceschi, PJ Facchini - The Plant Cell, 2003 - academic.oup.com
Opium poppy produces a diverse array of pharmaceutical alkaloids, including the narcotic
analgesics morphine and codeine. The benzylisoquinoline alkaloids of opium poppy …

Morphine biosynthesis in opium poppy involves two cell types: sieve elements and laticifers

A Onoyovwe, JM Hagel, X Chen, MF Khan… - The Plant …, 2013 - academic.oup.com
Immunofluorescence labeling and shotgun proteomics were used to establish the cell type–
specific localization of morphine biosynthesis in opium poppy (Papaver somniferum) …

Plant defense responses in opium poppy cell cultures revealed by liquid chromatography-tandem mass spectrometry proteomics

KG Zulak, MF Khan, J Alcantara, DC Schriemer… - Molecular & Cellular …, 2009 - ASBMB
Opium poppy (Papaver somniferum) produces a diverse array of bioactive
benzylisoquinoline alkaloids, including the narcotic analgesic morphine and the …

Neopinone isomerase is involved in codeine and morphine biosynthesis in opium poppy

M Dastmalchi, X Chen, JM Hagel, L Chang… - Nature chemical …, 2019 - nature.com
The isomerization of neopinone to codeinone is a critical step in the biosynthesis of opiate
alkaloids in opium poppy. Previously assumed to be spontaneous, the process is in fact …

The roles of latex and the vascular bundle in morphine biosynthesis in the opium poppy, Papaver somniferum

M Weid, J Ziegler, TM Kutchan - Proceedings of the …, 2004 - National Acad Sciences
The opium poppy, Papaver somniferum, is one of mankind's oldest medicinal plants. Opium
poppy today is the commercial source of the narcotic analgesics morphine and codeine …

Characterization of proteins in latex of the opium poppy (Papaver somniferum) using two‐dimensional gel electrophoresis and microsequencing

G Decker, G Wanner, MH Zenk… - … an International Journal, 2000 - Wiley Online Library
The opium poppy (Papaver somniferum) belongs to the group of latex‐containing plants.
Latex is the milky‐like fluid within laticifer cells. In this study, poppy latex was analyzed with …

Phloem-specific localization of benzylisoquinoline alkaloid metabolism in opium poppy

N Ozber, PJ Facchini - Journal of Plant Physiology, 2022 - Elsevier
Opium poppy is the only commercial source of the narcotic analgesics morphine and
codeine, and semi-synthetic derivatives of the natural opiate precursor thebaine, including …

A pathogenesis-related 10 protein catalyzes the final step in thebaine biosynthesis

X Chen, JM Hagel, L Chang, JE Tucker… - Nature chemical …, 2018 - nature.com
The ultimate step in the formation of thebaine, a pentacyclic opiate alkaloid readily
converted to the narcotic analgesics codeine and morphine in the opium poppy, has long …

The opium poppy genome and morphinan production

L Guo, T Winzer, X Yang, Y Li, Z Ning, Z He, R Teodor… - Science, 2018 - science.org
Morphinan-based painkillers are derived from opium poppy (Papaver somniferum L.). We
report a draft of the opium poppy genome, with 2.72 gigabases assembled into 11 …