The proper functioning of the pathways that are involved in the sensing and management of
nutrients is central to metabolic homeostasis and is therefore among the most fundamental …

Highly ordered interactions between immune and metabolic responses are evolutionarily
conserved and paramount for tissue and organismal health. Disruption of these interactions …

Obesity, type 2 diabetes, and other metabolic disorders have a large impact on global
health, especially in Western countries. An important hallmark of metabolic disorders is …

Nutrient content and nutrient timing are considered key regulators of human health and a
variety of diseases and involve complex interactions with the mucosal immune system. In …

Mammals possess a remarkable ability to maintain and defend a constant internal milieu
against diverse environmental threats. Unsurprisingly, the two systems tasked with these …

In addition to the immune system's traditional roles of conferring anti-infectious and anti-
neoplastic protection, it has been recently implicated in the regulation of systemic metabolic …

Pathogen and nutrient response pathways are evolutionarily conserved and highly
integrated to regulate metabolic and immune homeostasis. Excessive nutrients can be …

Recent studies have demonstrated that tissue homeostasis and metabolic function are
dependent on distinct tissue-resident immune cells that form functional cell circuits with …

The study of the intersection of immunology and metabolism is a growing field fueled by the
increased prevalence of obesity-associated pathologies. Importantly, the capacity of the …

The macronutrients glucose, lipids, and amino acids are the major components that maintain
life. The ability of cells to sense and respond to fluctuations in these nutrients is a crucial …