We report on observations of the global methylation/demethylation pattern of both pronuclei
in human zygotes and in early embryos up to the blastocyst stage. Our results demonstrate …

The fertilized mouse egg actively demethylates the paternal genome within a few hours after
fertilization, whereas the maternal genome is only passively demethylated by a replication …

In the normal diploid mouse embryo, active demethylation of the paternal genome but not of
the maternal genome occurs within only a few hours and in a highly coordinated fashion as …

Virtually all mammalian species including mouse, rat, pig, cow, and human, but not sheep
and rabbit, undergo genome‐wide epigenetic reprogramming by demethylation of the male …

In situ alterations of DNA methylation were studied between 14 d postcoitum and 4 d
postpartum in Sertoli cells and germ cells from mouse testis, using anti-5-methylcytosine …

The methylation status of three highly repeated sequences was studied in sperm, eggs and
preimplantation embryos with different combinations of parental chromosomes. High levels …

This paper shows stage-and tissue-specific global demethylation and remethylation
occurring during embryonic development. The egg genome is strikingly undermethylated …

DNA methylation is essential for the control of a number of biological mechanisms in
mammals [1]. Mammalian development is accompanied by two major waves of genome …

Active demethylation of the paternal genome but not of the maternal genome occurs in
fertilized mouse, rat, pig, and bovine zygotes. To study whether this early demethylation …

Methylation patterns of specific genes have been studied by polymerase chain reaction and
found to undergo dynamic changes in the germ line and early embryo. Some CpG sites are …