Inorganic Polyphosphate Affects Biofilm Assembly, Capsule Formation, and Virulence of Hypervirulent ST23 Klebsiella pneumoniae

D Rojas, AE Marcoleta, M Gálvez-Silva… - ACS Infectious …, 2024 - ACS Publications
The emergence of hypervirulent Klebsiella pneumoniae (hvKP) strains poses a significant
threat to public health due to high mortality rates and propensity to cause severe community …

StkP-and PhpP-mediated posttranslational modifications modulate the S. pneumoniae metabolism, polysaccharide capsule, and virulence

S Kant, Y Sun, V Pancholi - Infection and immunity, 2023 - Am Soc Microbiol
ABSTRACT Pneumococcal Ser/Thr kinase (StkP) and its cognate phosphatase (PhpP) play
a crucial role in bacterial cytokinesis. However, their individual and reciprocal metabolic and …

Phosphoproteomics of Klebsiella pneumoniae NTUH-K2044 reveals a tight link between tyrosine phosphorylation and virulence

MH Lin, TL Hsu, SY Lin, YJ Pan, JT Jan… - Molecular & Cellular …, 2009 - ASBMB
Encapsulated Klebsiella pneumoniae is the predominant causative agent of pyogenic liver
abscess, an emerging infectious disease that often complicates metastatic meningitis or …

Prophylaxis and Treatment against Klebsiella pneumoniae: Current Insights on This Emerging Anti-Microbial Resistant Global Threat

V Arato, MM Raso, G Gasperini… - International Journal of …, 2021 - mdpi.com
Klebsiella pneumoniae (Kp) is an opportunistic pathogen and the leading cause of
healthcare-associated infections, mostly affecting subjects with compromised immune …

Distinct epigenetic signatures of classical and hypervirulent Klebsiella pneumoniae

D Ghosh, A Pal, S Mohapatra, S Raj, P Vivekanandan - Msphere, 2024 - Am Soc Microbiol
Emergence and spread of the hypervirulent pathotype of Klebsiella pneumoniae have
significantly increased infection rates in community as well as healthcare settings. There is …

[HTML][HTML] Phosphoenolpyruvate phosphotransferase system components positively regulate Klebsiella biofilm formation

YT Horng, CJ Wang, WT Chung, HJ Chao… - Journal of microbiology …, 2018 - Elsevier
Abstract Background/Purpose Klebsiella pneumoniae is one of the leading causes of device-
related infections (DRIs), which are associated with attachment of bacteria to these devices …

Polyphosphate kinase 1 is involved in formation, the morphology and ultramicrostructure of biofilm of Mycobacterium smegmatis and its survivability in macrophage

C He, B Li, Z Gong, S Huang, X Liu, J Wang, J Xie… - Heliyon, 2023 - cell.com
The most unique characteristic of Mycobacterium tuberculosis is persistence in the human
host, and the biofilm formation is related to the persistance. Polyphosphate (polyP) kinase 1 …

Evolution of virulence, fitness, and carbapenem resistance transmission in ST23 hypervirulent Klebsiella pneumoniae with the capsular polysaccharide synthesis …

S Wang, Q Ding, Y Zhang, A Zhang, Q Wang… - Microbiology …, 2022 - Am Soc Microbiol
Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) is recognized as a
threat worldwide, but the mechanisms underlying its emergence remain unclear. As most …

Regulation of biofilm formation in Klebsiella pneumoniae

Y Li, M Ni - Frontiers in Microbiology, 2023 - frontiersin.org
Klebsiella pneumoniae is an important Gram-negative opportunistic pathogen that is
responsible for a variety of nosocomial and community-acquired infections. Klebsiella …

The KbvR regulator contributes to capsule production, outer membrane protein biosynthesis, antiphagocytosis, and virulence in Klebsiella pneumoniae

L Xu, M Wang, J Yuan, H Wang, M Li… - Infection and …, 2021 - Am Soc Microbiol
Klebsiella pneumoniae is an opportunistic pathogen that mostly affects patients with
weakened immune systems, but a few serotypes (especially K1 and K2) are highly invasive …