RhoA/ROCK2 signalling is enhanced by PDGF‐AA in fibro‐adipogenic progenitor cells: implications for Duchenne muscular dystrophy
E Fernández‐Simón, X Suárez‐Calvet… - Journal of Cachexia …, 2022 - Wiley Online Library
Background The lack of dystrophin expression in Duchenne muscular dystrophy (DMD)
induces muscle fibre and replacement by fibro‐adipose tissue. Although the role of some …
induces muscle fibre and replacement by fibro‐adipose tissue. Although the role of some …
RhoA/ROCK signalling activated by ARHGEF3 promotes muscle weakness via autophagy in dystrophic mdx mice
Background Duchenne muscular dystrophy (DMD), caused by dystrophin deficiency, leads
to progressive and fatal muscle weakness through yet‐to‐be‐fully deciphered molecular …
to progressive and fatal muscle weakness through yet‐to‐be‐fully deciphered molecular …
[HTML][HTML] Stromal cell-derived factors in Duchenne muscular dystrophy
E Abdel-Salam, IE Abdel-Meguid, R Shatla… - Acta …, 2010 - ncbi.nlm.nih.gov
Duchenne muscular dystrophy (DMD) is characterized by increased muscle damage and an
abnormal blood flow after muscle contraction leading to a state of functional ischemia …
abnormal blood flow after muscle contraction leading to a state of functional ischemia …
PDGFRα signalling promotes fibrogenic responses in collagen‐producing cells in Duchenne muscular dystrophy
N Ieronimakis, A Hays, A Prasad… - The Journal of …, 2016 - Wiley Online Library
Fibrosis is a characteristic of Duchenne muscular dystrophy (DMD), yet the cellular and
molecular mechanisms responsible for DMD fibrosis are poorly understood. Utilizing the …
molecular mechanisms responsible for DMD fibrosis are poorly understood. Utilizing the …
Dystrophin restoration in skeletal, heart and skin arrector pili smooth muscle of mdx mice by ZM2 NP–AON complexes
A Ferlini, P Sabatelli, M Fabris, E Bassi, S Falzarano… - Gene Therapy, 2010 - nature.com
Potentially viable therapeutic approaches for Duchenne muscular dystrophy (DMD) are now
within reach. Indeed, clinical trials are currently under way. Two crucial aspects still need to …
within reach. Indeed, clinical trials are currently under way. Two crucial aspects still need to …
Nitric oxide controls fat deposition in dystrophic skeletal muscle by regulating fibro-adipogenic precursor differentiation
N Cordani, V Pisa, L Pozzi, C Sciorati, E Clementi - Stem cells, 2014 - academic.oup.com
Duchenne muscular dystrophy (DMD) is an hereditary disease characterized by loss of
muscle fibers and their progressive substitution by fat and fibrous tissue. Mesenchymal fibro …
muscle fibers and their progressive substitution by fat and fibrous tissue. Mesenchymal fibro …
Targeting fibrosis in Duchenne muscular dystrophy
L Zhou, H Lu - Journal of Neuropathology & Experimental …, 2010 - academic.oup.com
Duchenne muscular dystrophy (DMD) is the most common genetic muscle disease affecting
1 in 3,500 live male births. It is an X-linked recessive disease caused by a defective …
1 in 3,500 live male births. It is an X-linked recessive disease caused by a defective …
[HTML][HTML] Total absence of dystrophin expression exacerbates ectopic myofiber calcification and fibrosis and alters macrophage infiltration patterns
CNJ Young, MRF Gosselin, R Rumney… - The American Journal of …, 2020 - Elsevier
Duchenne muscular dystrophy (DMD) causes severe disability and death of young men
because of progressive muscle degeneration aggravated by sterile inflammation. DMD is …
because of progressive muscle degeneration aggravated by sterile inflammation. DMD is …
Understanding the process of fibrosis in Duchenne muscular dystrophy
Y Kharraz, J Guerra, P Pessina… - BioMed research …, 2014 - Wiley Online Library
Fibrosis is the aberrant deposition of extracellular matrix (ECM) components during tissue
healing leading to loss of its architecture and function. Fibrotic diseases are often associated …
healing leading to loss of its architecture and function. Fibrotic diseases are often associated …
Insights into the pathogenic secondary symptoms caused by the primary loss of dystrophin
Duchenne muscular dystrophy (DMD) is an X-linked genetic disease in which the dystrophin
gene is mutated, resulting in dysfunctional dystrophin protein. Without dystrophin, the …
gene is mutated, resulting in dysfunctional dystrophin protein. Without dystrophin, the …