Three-dimensional modeling and computational analysis of the human cornea considering distributed collagen fibril orientations

A Pandolfi, GA Holzapfel - 2008 - asmedigitalcollection.asme.org
Experimental tests on human corneas reveal distinguished reinforcing collagen lamellar
structures that may be well described by a structural constitutive model considering …

A model for the human cornea: constitutive formulation and numerical analysis

A Pandolfi, F Manganiello - Biomechanics and modeling in …, 2006 - Springer
The human cornea (the external lens of the eye) has the macroscopic structure of a thin
shell, originated by the organization of collagen lamellae parallel to the middle surface of the …

Biomechanical model of the human cornea: considering shear stiffness and regional variation of collagen anisotropy and density

C Whitford, H Studer, C Boote, KM Meek… - Journal of the mechanical …, 2015 - Elsevier
A numerical model based on continuum mechanics theory has been developed which
represents the 3D anisotropic behaviour of the corneal stroma. Experimental data has been …

Lamellar orientation in human cornea in relation to mechanical properties

C Boote, S Dennis, Y Huang, AJ Quantock… - Journal of structural …, 2005 - Elsevier
We have applied wide-angle X-ray scattering to the human cornea in order to quantify the
relative number of stromal collagen fibrils directed along the two preferred corneal lamellar …

A computational remodeling approach to predict the physiological architecture of the collagen fibril network in corneo-scleral shells

R Grytz, G Meschke - Biomechanics and modeling in mechanobiology, 2010 - Springer
Organized collagen fibrils form complex networks that introduce strong anisotropic and
highly nonlinear attributes into the constitutive response of human eye tissues. Physiological …

The role of 3-D collagen organization in stromal elasticity: a model based on X-ray diffraction data and second harmonic-generated images

SJ Petsche, PM Pinsky - Biomechanics and modeling in mechanobiology, 2013 - Springer
Examining the cross-section of the human cornea with second harmonic-generated (SHG)
imaging shows that many lamellae do not lie parallel to the cornea's anterior surface but …

[HTML][HTML] The hierarchical response of human corneal collagen to load

JS Bell, S Hayes, C Whitford, J Sanchez-Weatherby… - Acta biomaterialia, 2018 - Elsevier
Fibrillar collagen in the human cornea is integral to its function as a transparent lens of
precise curvature, and its arrangement is now well-characterised in the literature. While …

[HTML][HTML] Nonlinear optical macroscopic assessment of 3-D corneal collagen organization and axial biomechanics

M Winkler, D Chai, S Kriling, CJ Nien… - … & visual science, 2011 - tvst.arvojournals.org
Purpose.: To characterize and quantify the collagen fiber (lamellar) organization of human
corneas in three dimensions by using nonlinear optical high-resolution macroscopy (NLO …

Collagen and mature elastic fibre organisation as a function of depth in the human cornea and limbus

CS Kamma-Lorger, C Boote, S Hayes, J Moger… - Journal of structural …, 2010 - Elsevier
A network of circumferentially oriented collagen fibrils exists in the periphery of the human
cornea, which is thought to be pivotal in maintaining corneal biomechanical stability and …

[HTML][HTML] A mechanical model of the cornea considering the crimping morphology of collagen fibrils

X Liu, L Wang, J Ji, W Yao, W Wei, J Fan… - … & visual science, 2014 - tvst.arvojournals.org
Purpose.: To develop a mechanical model with which to investigate the relationship
between the crimping morphology of collagen fibrils and the nonlinear mechanical behavior …