Inflammatory cytokines are necessary for an acute response to injury and the progressive
healing process. However, when this acute response does not resolve and becomes …

Osteopontin (OPN) is a multifunctional molecule highly expressed in chronic inflammatory
and autoimmune diseases, and it is specifically localized in and around inflammatory cells …

Atherosclerosis is a chronic inflammatory process of the vessel wall with systemic correlates.
It is now well established that patients' outcome is tightly linked to atherosclerotic plaque …

Osteopontin (OPN) was initially identified in osteoblasts as a mineralization-modulatory
matrix protein. Recently, OPN has been studied as a multifunctional protein that is …

Unprecedented advances in secondary prevention have greatly improved the prognosis of
cardiovascular diseases (CVDs); however, CVDs remain a leading cause of death globally …

Osteopontin (OPN) is a matricellular protein that mediates diverse biological functions. OPN
is involved in normal physiological processes and is implicated in the pathogenesis of a …

Osteopontin (OPN) is a soluble secreted phosphoprotein that binds with high affinity to
several different integrins. While numerous activities have been ascribed to OPN in vitro …

Introduction 3. Osteopontin Structure and Cell Binding 4. Role in Vascular Disease 4.1. Role
in angiogenesis 4.2. Role in inflammation 4.3. Role in calcification 4.4. Aneurysms …

Molecular biology has greatly enhanced our ability to identify molecules expressed as a part
of the vascular response to injury. Among these, osteopontin is of particular interest …

A matricellular protein, osteopontin (OPN), is expressed in response to mechanical stress
and similar stimuli in the heart, integrates the inter-ECM signal transduction network of …