Chromatin is the context for all DNA-based molecular processes taking place in the cell
nucleus. The initial chromatin structure at the site of the DNA damage determines both …

Genomic instability is both a hallmark of cancer and a major contributing factor to tumor
development. Central to the maintenance of genome stability is the repair of DNA damage …

Complex mechanisms are in place to maintain genome stability. Ubiquitination of chromatin
plays a central role in these mechanisms. The ever-growing complexity of the ubiquitin (Ub) …

In the cell nucleus, DNA damage signaling and repair machineries operate on a chromatin
substrate, the integrity of which is critical for cell function and viability. Here, we review …

The intimate relationship between DNA double-strand break (DSB) repair and cancer
susceptibility has sparked profound interest in how transactions on DNA and chromatin …

Cells are constantly exposed to numerous genotoxic stresses that induce DNA damage.
DNA double-strand breaks (DSBs) are among the most serious damages and should be …

To counteract the adverse effects of various DNA lesions, cells have evolved an array of
diverse repair pathways to restore DNA structure and to coordinate repair with cell cycle …

Eukaryotic cells package their genomes around histone octamers. In response to DNA
damage, checkpoint activation in yeast induces core histone degradation resulting in 20 …

In recent years, several ATP-dependent chromatin-remodeling complexes and covalent
histone modifications have been implicated in the response to double-stranded DNA breaks …

The ability to sense and respond appropriately to genetic lesions is vitally important to
maintain the integrity of the genome. Emerging evidence indicates that various modulations …