Bipolar disorder (BD) and major depressive disorder (MDD) are heritable neuropsychiatric
disorders associated with disrupted circadian rhythms. The hypothesis that circadian clock …

Mood state alterations are often accompanied by disruptions of daily rhythms of physiology.
Circadian rhythms of physiology are controlled by a central clock harbored in the …

Nearly all patients with bipolar disorder have severely disrupted circadian rhythms.
Treatment with mood stabilizers can restore these daily rhythms, and this is correlated with …

Patients suffering from neuropsychiatric disorders often exhibit a loss of regulation of their
biological rhythms which leads to altered sleep/wake cycle, body temperature rhythm and …

The rhythms of life are ever pervasive, touching almost every aspect of our lives. We are
finely tuned to the cycle of light and dark, so that we normally sleep during the night and are …

Altered behavioral rhythms are a fundamental diagnostic feature of mood disorders. Patients
report worse subjective sleep and objective measures confirm this, implicating a role for …

Mood disorders are serious diseases that affect a large portion of the population. There have
been many hypotheses put forth over the years to explain the development of major …

BACKGROUND: Circadian rhythm abnormalities are strongly associated with bipolar
disorder; however the role of circadian genes in mood regulation is unclear. Previously, we …

Circadian clocks are present in nearly all tissues of an organism, including the brain. The
brain is not only the site of the master coordinator of circadian rhythms located in the …

Mood disorders, including major depression, bipolar disorder, and seasonal affective
disorder, are debilitating disorders that affect a significant portion of the global population …