Superantigens trigger an excessive cellular immune response, leading to toxic shock. We
have designed a peptide antagonist that inhibits superantigen-induced expression of human …

Superantigens are powerful microbial toxins that activate the immune system by binding to
class II major histocompatibility complex and T-cell receptor molecules. They cause a …

Superantigens in Human Disease Page 1 Journal of Clinical Immunology, Vol. 19, No. 3,
1999 Special Article Superantigens in Human Disease ALEJANDRO BERNAL, THOMAS …

Full T-cell activation requires interaction between the costimulatory receptors B7-2 and
CD28. By binding CD28, bacterial superantigens elicit harmful inflammatory cytokine …

Superantigens are interesting for several reasons. They exhibit unusual T-cell activation
characteristics, they allow to follow in vivo ligand-reactive T cells, they cause T-cell-mediated …

Superantigens stimulate powerful T-cell responses that can have marked effects in vivo,
sometimes leading to shock or even death. The demonstration that strong T-cell responses …

Superantigens interact with the immune system by binding to major histocompatibility
complex (MHG) class II proteins and activating T cells through the variable region of the T …

Normally, when a person's im mune system encounters a pro tein made by a virus or other
microbe, fewer than one in"'10,000 of the white blood cells known as T lym phocytes react …

Bacterial superantigens are believed to cause septic shock, although, because of the lack of
superantigen-sensitive infection models, proof that superantigenicity underlies shock …

Staphylococcal and streptococcal superantigens are exotoxins that may be linked to many
human pathologies involving impaired immune functions. Despite considerable sequence …