Background: Various cancer cells share critical physiologic changes that promote malignant
development. Progranulin [PGRN], a growth factor, has major biological impact on several …

BACKGROUND: Acute Myeloid leukemia (AML) is a clonal, malignant disease of
hematopoietic tissues that is characterized by the accumulation of blast cells, principally in …

Background Progranulin (PGRN) is a highly conserved secreted protein that is expressed in
multiple cell types, both in the Central Nervous System (CNS) and in peripheral tissues. Both …

Increased expression of progranulin (PGRN) has been reported in some hematological
cancers, but limited information regarding its significance in acute lymphoblastic leukemia …

Background Elevated serum progranulin (PGRN) levels have been associated with a wide
range of different human malignancies. However, data available on the role of PGRN in …

Introduction: Carcinoma mammae is a malignant tumor that develops from breast cells and
has the potential to invade the surrounding tissue (invasive) or metastasize to other parts of …

Progranulin has been considered to be a poor prognostic biomarker for some types of
malignancies. However, the clinical significance of serum progranulin level and the …

Progranulin (PGRN) is a secreted protein that can regulate cell cycle progression, cell
motility, and tumorigenesis. The PGRN expression in hematological malignancies is limited …

The enzyme-linked immunosorbent assay (ELISA) is a well-established methodology for
detection of analytes in various biological fluids. The assay described herein has been …

Objective: To investigate the effects of progranulin on migration and invasion of human
colon cancer cells. Study Design: An experimental study. Place and Duration of Study …