The hypothalamic–pituitary–adrenal (HPA) axis and the inflammatory response system have
been suggested as pathophysiological mechanisms implicated in the etiology of major …

Depression is the most common psychiatric disorder worldwide. The burden of disease for
depression goes beyond functioning and quality of life and extends to somatic health …

Background The link between the abnormalities of the Hypothalamic-pituitary-adrenal (HPA)
axis and depression has been one of the most consistently reported findings in psychiatry. At …

Recent findings have established a connection between inflammation and major depression
and specifically the role of the hypothalamic–pituitary–adrenal (HPA) axis in depression …

Meta-analyses support the involvement of different pathophysiological mechanisms
(inflammation, hypothalamic–pituitary (HPA)-axis, neurotrophic growth and vitamin D) in …

BACKGROUND: Recent studies showed an activation of the cytokine system and the HPA
axis in major depression, although with inconsistent results. While the non-melancholic …

BACKGROUND:: Results on the association between depression and the hypothalamo-
pituitary-adrenal (HPA) axis have been inconsistent, possibly due to heterogeneity of the …

The pathophysiology of major depressive disorder (MDD) remains elusive, and there is no
established biochemical marker used in the daily clinical setting. This situation may result in …

The HPA axis in major depression: classical theories and new developments: Trends in
Neurosciences Skip to Main Content Advertisement Trendsin Neurosciences This journal offers …

Enhanced activity of the hypothalamic-pituitary-adrenal (HPA) axis, involving elevated
secretion of corticotropin-releasing hormone (CRH), is considered a key neurobiological …