Repurposing phytochemicals as anti‐virulent agents to attenuate quorum sensing‐regulated virulence factors and biofilm formation in Pseudomonas aeruginosa

J Chadha, K Harjai, S Chhibber - Microbial biotechnology, 2022 - Wiley Online Library
Unregulated consumption and overexploitation of antibiotics have paved the way for
emergence of antibiotic‐resistant strains and 'superbugs'. Pseudomonas aeruginosa is …

Revisiting the virulence hallmarks of Pseudomonas aeruginosa: a chronicle through the perspective of quorum sensing

J Chadha, K Harjai, S Chhibber - Environmental microbiology, 2022 - Wiley Online Library
Pseudomonas aeruginosa is an opportunistic pathogen and the leading cause of mortality
among immunocompromised patients in clinical setups. The hallmarks of virulence in P …

[HTML][HTML] A Novel Use of Allopurinol as A Quorum-Sensing Inhibitor in Pseudomonas aeruginosa

AA Saqr, MF Aldawsari, ES Khafagy, MA Shaldam… - Antibiotics, 2021 - mdpi.com
Pseudomonas aeruginosa can cause a variety of healthcare-associated infections by its
arsenal of virulence factors. Virulence factor production is largely controlled by the cell-to …

[HTML][HTML] Quorum Sensing Inhibitors to Quench P. aeruginosa Pathogenicity

M Duplantier, E Lohou, P Sonnet - Pharmaceuticals, 2021 - mdpi.com
The emergence and the dissemination of multidrug-resistant bacteria constitute a major
public health issue. Among incriminated Gram-negative bacteria, Pseudomonas aeruginosa …

[HTML][HTML] Natural quorum sensing inhibitors effectively downregulate gene expression of Pseudomonas aeruginosa virulence factors

SAKS Ahmed, M Rudden, TJ Smyth… - Applied microbiology …, 2019 - Springer
At present, anti-virulence drugs are being considered as potential therapeutic alternatives
and/or adjuvants to currently failing antibiotics. These drugs do not kill bacteria but inhibit …

[HTML][HTML] In-depth Profiling of MvfR-Regulated Small Molecules in Pseudomonas aeruginosa after Quorum Sensing Inhibitor Treatment

G Allegretta, CK Maurer, J Eberhard, D Maura… - Frontiers in …, 2017 - frontiersin.org
Pseudomonas aeruginosa is a Gram-negative bacterium, which causes opportunistic
infections in immuno-compromised individuals. Due to its multiple resistances toward …

Understanding resistance acquisition by Pseudomonas aeruginosa and possible pharmacological approaches in palliating its pathogenesis

M Thakur, Y Kumar, V Yadav, A Pramanik… - Biochemical …, 2023 - Elsevier
Pseudomonas aeruginosa can utilize various virulence factors necessary for host infection
and persistence. These virulence factors include pyocyanin, proteases, exotoxins, 2-heptyl-4 …

Identification of FDA-Approved Drugs as Antivirulence Agents Targeting the pqs Quorum-Sensing System of Pseudomonas aeruginosa

F D'Angelo, V Baldelli, N Halliday… - Antimicrobial Agents …, 2018 - Am Soc Microbiol
The long-term use of antibiotics has led to the emergence of multidrug-resistant bacteria. A
promising strategy to combat bacterial infections aims at hampering their adaptability to the …

[HTML][HTML] Coumarin Reduces Virulence and Biofilm Formation in Pseudomonas aeruginosa by Affecting Quorum Sensing, Type III Secretion and C-di-GMP Levels

Y Zhang, A Sass, H Van Acker, J Wille… - Frontiers in …, 2018 - frontiersin.org
As one of the major pathogens in wound infections, Pseudomonas aeruginosa produces
several virulence factors and forms biofilms; these processes are under the regulation of …

[HTML][HTML] Attenuation of Pseudomonas aeruginosa Quorum Sensing by Natural Products: Virtual Screening, Evaluation and Biomolecular Interactions

L Zhong, V Ravichandran, N Zhang, H Wang… - International journal of …, 2020 - mdpi.com
Natural products play vital roles against infectious diseases since ancient times and most
drugs in use today are derived from natural sources. Worldwide, multi-drug resistance …