Repurposing phytochemicals as anti‐virulent agents to attenuate quorum sensing‐regulated virulence factors and biofilm formation in Pseudomonas aeruginosa
Unregulated consumption and overexploitation of antibiotics have paved the way for
emergence of antibiotic‐resistant strains and 'superbugs'. Pseudomonas aeruginosa is …
emergence of antibiotic‐resistant strains and 'superbugs'. Pseudomonas aeruginosa is …
Revisiting the virulence hallmarks of Pseudomonas aeruginosa: a chronicle through the perspective of quorum sensing
Pseudomonas aeruginosa is an opportunistic pathogen and the leading cause of mortality
among immunocompromised patients in clinical setups. The hallmarks of virulence in P …
among immunocompromised patients in clinical setups. The hallmarks of virulence in P …
[HTML][HTML] A Novel Use of Allopurinol as A Quorum-Sensing Inhibitor in Pseudomonas aeruginosa
AA Saqr, MF Aldawsari, ES Khafagy, MA Shaldam… - Antibiotics, 2021 - mdpi.com
Pseudomonas aeruginosa can cause a variety of healthcare-associated infections by its
arsenal of virulence factors. Virulence factor production is largely controlled by the cell-to …
arsenal of virulence factors. Virulence factor production is largely controlled by the cell-to …
[HTML][HTML] Quorum Sensing Inhibitors to Quench P. aeruginosa Pathogenicity
M Duplantier, E Lohou, P Sonnet - Pharmaceuticals, 2021 - mdpi.com
The emergence and the dissemination of multidrug-resistant bacteria constitute a major
public health issue. Among incriminated Gram-negative bacteria, Pseudomonas aeruginosa …
public health issue. Among incriminated Gram-negative bacteria, Pseudomonas aeruginosa …
[HTML][HTML] Natural quorum sensing inhibitors effectively downregulate gene expression of Pseudomonas aeruginosa virulence factors
At present, anti-virulence drugs are being considered as potential therapeutic alternatives
and/or adjuvants to currently failing antibiotics. These drugs do not kill bacteria but inhibit …
and/or adjuvants to currently failing antibiotics. These drugs do not kill bacteria but inhibit …
[HTML][HTML] In-depth Profiling of MvfR-Regulated Small Molecules in Pseudomonas aeruginosa after Quorum Sensing Inhibitor Treatment
G Allegretta, CK Maurer, J Eberhard, D Maura… - Frontiers in …, 2017 - frontiersin.org
Pseudomonas aeruginosa is a Gram-negative bacterium, which causes opportunistic
infections in immuno-compromised individuals. Due to its multiple resistances toward …
infections in immuno-compromised individuals. Due to its multiple resistances toward …
Understanding resistance acquisition by Pseudomonas aeruginosa and possible pharmacological approaches in palliating its pathogenesis
Pseudomonas aeruginosa can utilize various virulence factors necessary for host infection
and persistence. These virulence factors include pyocyanin, proteases, exotoxins, 2-heptyl-4 …
and persistence. These virulence factors include pyocyanin, proteases, exotoxins, 2-heptyl-4 …
Identification of FDA-Approved Drugs as Antivirulence Agents Targeting the pqs Quorum-Sensing System of Pseudomonas aeruginosa
F D'Angelo, V Baldelli, N Halliday… - Antimicrobial Agents …, 2018 - Am Soc Microbiol
The long-term use of antibiotics has led to the emergence of multidrug-resistant bacteria. A
promising strategy to combat bacterial infections aims at hampering their adaptability to the …
promising strategy to combat bacterial infections aims at hampering their adaptability to the …
[HTML][HTML] Coumarin Reduces Virulence and Biofilm Formation in Pseudomonas aeruginosa by Affecting Quorum Sensing, Type III Secretion and C-di-GMP Levels
Y Zhang, A Sass, H Van Acker, J Wille… - Frontiers in …, 2018 - frontiersin.org
As one of the major pathogens in wound infections, Pseudomonas aeruginosa produces
several virulence factors and forms biofilms; these processes are under the regulation of …
several virulence factors and forms biofilms; these processes are under the regulation of …
[HTML][HTML] Attenuation of Pseudomonas aeruginosa Quorum Sensing by Natural Products: Virtual Screening, Evaluation and Biomolecular Interactions
L Zhong, V Ravichandran, N Zhang, H Wang… - International journal of …, 2020 - mdpi.com
Natural products play vital roles against infectious diseases since ancient times and most
drugs in use today are derived from natural sources. Worldwide, multi-drug resistance …
drugs in use today are derived from natural sources. Worldwide, multi-drug resistance …
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