The central role of fibrinolytic response in COVID-19—a hematologist's perspective

HC Kwaan, PF Lindholm - International journal of molecular sciences, 2021 - mdpi.com
The novel coronavirus disease (COVID-19) has many characteristics common to those in
two other coronavirus acute respiratory diseases, severe acute respiratory syndrome …

Coronavirus disease 2019: the role of the fibrinolytic system from transmission to organ injury and sequelae

HC Kwaan - Seminars in thrombosis and hemostasis, 2020 - thieme-connect.com
An initial cluster of severe viral pneumonia was discovered in early December 2019 in
Wuhan, China. It was found to be caused by a newly identified coronavirus, later named by …

[HTML][HTML] The suboptimal fibrinolytic response in COVID‐19 is dictated by high PAI‐1

CS Whyte, M Simpson, GB Morrow, CA Wallace… - Journal of Thrombosis …, 2022 - Elsevier
Background Severe COVID‐19 disease is associated with thrombotic complications and
extensive fibrin deposition. This study investigates whether the hemostatic complications in …

Altered fibrin clot structure and dysregulated fibrinolysis contribute to thrombosis risk in severe COVID-19

M Wygrecka, A Birnhuber, B Seeliger… - Blood …, 2022 - ashpublications.org
The high incidence of thrombotic events suggests a possible role of the contact system
pathway in COVID-19 pathology. In this study, we determined the altered levels of factor XII …

Plasma tissue plasminogen activator and plasminogen activator inhibitor-1 in hospitalized COVID-19 patients

Y Zuo, M Warnock, A Harbaugh, S Yalavarthi… - Scientific reports, 2021 - nature.com
Patients with coronavirus disease-19 (COVID-19) are at high risk for thrombotic arterial and
venous occlusions. However, bleeding complications have also been observed in some …

Thrombotic mechanism involving platelet activation, hypercoagulability and hypofibrinolysis in coronavirus disease 2019

H Wada, K Shiraki, H Shimpo, M Shimaoka… - International Journal of …, 2023 - mdpi.com
Coronavirus disease 2019 (COVID-19) has spread, with thrombotic complications being
increasingly frequently reported. Although thrombosis is frequently complicated in septic …

COVID-19 and sepsis are associated with different abnormalities in plasma procoagulant and fibrinolytic activity

EG Bouck, F Denorme, LA Holle… - … , and vascular biology, 2021 - Am Heart Assoc
Objective: Coronavirus disease 2019 (COVID-19) is associated with derangement in
biomarkers of coagulation and endothelial function and has been likened to the …

Fibrinolysis shutdown in COVID-19: clinical manifestations, molecular mechanisms, and therapeutic implications

JP Meizoso, HB Moore, EE Moore - Journal of the American College of …, 2021 - Elsevier
The COVID-19 pandemic has introduced a global public health threat unparalleled in our
history. The most severe cases are marked by ARDS attributed to microvascular thrombosis …

COVID-19-associated hyper-fibrinolysis: mechanism and implementations

G Jacob, A Aharon, B Brenner - Frontiers in Physiology, 2020 - frontiersin.org
The emerging novel coronavirus disease (COVID-19), which is caused by the SARS-CoV-2
presents with high infectivity, morbidity and mortality. It presenting a need for immediate …

Renin–Angiotensin system and fibrinolytic pathway in COVID-19: One-way skepticism

HM Al-Kuraishy, NR Hussien, MS Al-Naimi… - Biomedical and …, 2020 - journals.lww.com
Severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection is a recent
pandemic infectious disease caused by severe acute respiratory syndrome coronavirus …