Targeting pancreatic stellate cells in chronic pancreatitis: Focus on therapeutic drugs and natural compounds

Y Wu, C Zhang, M Guo, W Hu, Y Qiu, M Li… - Frontiers in …, 2022 - frontiersin.org
Chronic pancreatitis (CP) is a precancerous illness linked to pancreatic ductal
adenocarcinoma (PDAC), although the evolutionary mechanism is uncertain. CP is …

Novel therapeutics to treat chronic pancreatitis: targeting pancreatic stellate cells and macrophages

S Iyer, M Enman, P Sahay, V Dudeja - Expert Review of …, 2024 - Taylor & Francis
Introduction Chronic pancreatitis (CP) is a persistent, recurrent, and progressive disorder
that is characterized by chronic inflammation and irreversible fibrosis of the pancreas. It is …

Pancreatic Stellate Cells and the Targeted Therapeutic Strategies in Chronic Pancreatitis

M Chang, W Chen, R Xia, Y Peng, P Niu, H Fan - Molecules, 2023 - mdpi.com
Chronic pancreatitis (CP) is a disease characterized by inflammatory recurrence that
accompanies the development of pancreatic fibrosis. As the mystery of CP pathogenesis is …

[HTML][HTML] Selective phytochemicals targeting pancreatic stellate cells as new anti-fibrotic agents for chronic pancreatitis and pancreatic cancer

P Ramakrishnan, WM Loh, SCB Gopinath… - … Pharmaceutica Sinica B, 2020 - Elsevier
Activated pancreatic stellate cells (PSCs) have been widely accepted as a key precursor of
excessive pancreatic fibrosis, which is a crucial hallmark of chronic pancreatitis (CP) and its …

Novel and experimental therapies in chronic pancreatitis

S Jagannath, PK Garg - Digestive Diseases and Sciences, 2017 - Springer
Chronic pancreatitis (CP) is a progressive inflammatory disease of the pancreas. The
currently available treatment of CP is aimed at controlling symptoms and managing …

Pancreatic stellate cells: new target in the treatment of chronic pancreatitis

R Talukdar, RK Tandon - Journal of gastroenterology and …, 2008 - Wiley Online Library
Chronic pancreatitis (CP) is characterized by progressive fibrosis, pain and/or loss of
exocrine and endocrine functions. Recent in vitro and in vivo experiments have proven …

Pancreatic stellate cells: what's new?

TCY Pang, JS Wilson, MV Apte - Current opinion in …, 2017 - journals.lww.com
Pancreatic stellate cells: what's new? : Current Opinion in Gastroenterology Pancreatic stellate
cells: what's new? : Current Opinion in Gastroenterology Log in or Register Subscribe to …

Activation and Regulation of Pancreatic Stellate Cells in Chronic Pancreatic Fibrosis: A Potential Therapeutic Approach for Chronic Pancreatitis

F Kong, Y Pan, D Wu - Biomedicines, 2024 - mdpi.com
In the complex progression of fibrosis in chronic pancreatitis, pancreatic stellate cells (PSCs)
emerge as central figures. These cells, initially in a dormant state characterized by the …

Chronic pancreatitis: potential future interventions

D Ansari, E Andersson, B Andersson… - Scandinavian journal …, 2010 - Taylor & Francis
Chronic pancreatitis is a common disorder of which the underlying pathogenic mechanisms
still are incompletely understood. In the last decade, increasing evidence has shown that …

Anti-fibrotic effects of phenolic compounds on pancreatic stellate cells

Z Lin, LC Zheng, HJ Zhang, SW Tsang… - BMC Complementary and …, 2015 - Springer
Background Pancreatic fibrosis is a prominent histopathological characteristic of chronic
pancreatitis and plausibly a dynamic process of transition to the development of pancreatic …