Background: The resistance to colistin and carbapenems in Klebsiella pneumoniae
infections have been associated with increased morbidity and mortality worldwide. A …

Colistin has long been a reserve drug used for the treatment of carbapenem resistant
Klebsiella pneumoniae. Carbapenem resistance in K. pneumoniae has been increasing and …

Colistin is one of the last-resort therapeutic agents to combat multidrug-resistant Gram-
negative bacteria (GNB) including Klebsiella pneumoniae. Although it happens rarely …

Methods: Sixty five isolates from blood, exudates and respiratory specimens collected
between 2016 and 2017 were studied. Colistin minimum inhibitory concentration (MIC) was …

Background Increasing use of colistin has led to the world-wide emergence of mobile
colistin resistant gene (mcr). The present study aimed to identify and characterise mcr and …

Background Over the last two decades, the prevalence of colistin resistance among the
members of Enterobacteriaceae has been increasing, particularly among Klebsiella …

Colistin resistance in Gram negative bacteria is mainly attributed to chromosomal mutations
in Two Component Systems (TCS) PhoPQ and PmrAB and plasmid-borne genes (mcr and …

Background Egypt has witnessed elevated incidence rates of multidrug-resistant Klebsiella
pneumonia e infections in intensive care units (ICUs). The treatment of these infections is …

Carbapenemases-producing K. pneumoniae are challenging antimicrobial therapy of
hospitalised patients, which is further complicated by colistin resistance. The aim of this …

The emergence of genetic mutations in chromosomal genes and the transmissible plasmid-
mediated colistin resistance gene may have helped in the spread of colistin resistance …