[HTML][HTML] Contribution of cyclooxygenase end products and oxidative stress to intrahepatic endothelial dysfunction in early non-alcoholic fatty liver disease

FJ Gonzalez-Paredes, G Hernández Mesa… - PLoS …, 2016 - journals.plos.org
Introduction Metabolic syndrome induces endothelial dysfunction, a surrogate marker of
cardiovascular disease. In parallel, metabolic syndrome is frequently associated with non …

[HTML][HTML] Sinusoidal endothelial dysfunction precedes inflammation and fibrosis in a model of NAFLD

M Pasarín, V La Mura, J Gracia-Sancho… - PloS one, 2012 - journals.plos.org
Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic
syndrome. Most morbidity associated with the metabolic syndrome is related to vascular …

[HTML][HTML] Vasoconstrictor antagonism improves functional and structural vascular alterations and liver damage in rats with early NAFLD

D van der Graaff, S Chotkoe, B De Winter, J De Man… - JHEP Reports, 2022 - Elsevier
Background & Aims Intrahepatic vascular resistance is increased in early non-alcoholic fatty
liver disease (NAFLD), potentially leading to tissue hypoxia and triggering disease …

Chronic intermittent hypoxia promotes early intrahepatic endothelial impairment in rats with nonalcoholic fatty liver disease

A Hernández-Bustabad… - American Journal …, 2022 - journals.physiology.org
Nonalcoholic fatty liver disease (NAFLD) is a progressive disease that ranges from simple
steatosis to cirrhosis. Obstructive sleep apnea syndrome (OSAS) and chronic intermittent …

[HTML][HTML] Endothelial cell dysfunction and nonalcoholic fatty liver disease (NAFLD): A concise review

N Nasiri-Ansari, T Androutsakos, CM Flessa, I Kyrou… - Cells, 2022 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases
worldwide. It is strongly associated with obesity, type 2 diabetes (T2DM), and other …

[HTML][HTML] Cholesterol exacerbates the pathophysiology of non-alcoholic steatohepatitis by Upregulating Hypoxia-Inducible factor 1 and modulating Microcirculatory …

ENGS Pereira, BP Araujo, KL Rodrigues, RR Silvares… - Nutrients, 2023 - mdpi.com
Cholesterol is a pivotal lipotoxic molecule that contributes to the progression of Non-
Alcoholic Steatohepatitis NASH). Additionally, microcirculatory changes are critical …

[HTML][HTML] Accumulation of free cholesterol and oxidized low-density lipoprotein is associated with portal inflammation and fibrosis in nonalcoholic fatty liver disease

CM Ho, SL Ho, YM Jeng, YS Lai, YH Chen, SC Lu… - Journal of …, 2019 - Springer
Background Macrophages engulf oxidized-LDL (oxLDL) leading to accumulation of cellular
cholesterol and formation of foam cells, which is a hallmark of atherosclerosis. Moreover …

[HTML][HTML] Metabolic inflammation as an instigator of fibrosis during non-alcoholic fatty liver disease

A Katsarou, II Moustakas, I Pyrina… - World journal of …, 2020 - ncbi.nlm.nih.gov
Non-alcoholic fatty liver disease (NAFLD) is characterized by excessive storage of fatty acids
in the form of triglycerides in hepatocytes. It is most prevalent in western countries and …

[HTML][HTML] Role of oxidative stress in the pathogenesis of non-alcoholic fatty liver disease: implications for prevention and therapy

JC Arroyave-Ospina, Z Wu, Y Geng, H Moshage - Antioxidants, 2021 - mdpi.com
Oxidative stress (OxS) is considered a major factor in the pathophysiology of inflammatory
chronic liver diseases, including non-alcoholic liver disease (NAFLD). Chronic impairment of …

[HTML][HTML] Deficiency of eNOS exacerbates early-stage NAFLD pathogenesis by changing the fat distribution

Y Nozaki, K Fujita, K Wada, M Yoneda… - BMC …, 2015 - Springer
Background Although many factors and molecules that are closely associated with non-
alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH) have been …