Orthogonal Translation for Site-Specific Installation of Post-translational Modifications

Q Gan, C Fan - Chemical Reviews, 2024 - ACS Publications
Post-translational modifications (PTMs) endow proteins with new properties to respond to
environmental changes or growth needs. With the development of advanced proteomics …

Functional analysis of protein post‐translational modifications using genetic codon expansion

T Peng, T Das, K Ding, HC Hang - Protein Science, 2023 - Wiley Online Library
Post‐translational modifications (PTMs) of proteins not only exponentially increase the
diversity of proteoforms, but also contribute to dynamically modulating the localization …

Recent development of genetic code expansion for posttranslational modification studies

H Chen, S Venkat, P McGuire, Q Gan, C Fan - Molecules, 2018 - mdpi.com
Nowadays advanced mass spectrometry techniques make the identification of protein
posttranslational modifications (PTMs) much easier than ever before. A series of proteomic …

Chemical biology approaches for studying posttranslational modifications

A Yang, K Cho, HS Park - RNA biology, 2018 - Taylor & Francis
Posttranslational modification (PTM) is a key mechanism for regulating diverse protein
functions, and thus critically affects many essential biological processes. Critical for …

New Strategies for Probing the Biological Functions of Protein Post-translational Modifications in Mammalian Cells with Genetic Code Expansion

W Ding, H Zhao, Y Chen, S Lin - Accounts of Chemical Research, 2023 - ACS Publications
Conspectus Protein post-translational modification (PTM) is a major mechanism for
functional diversification of the human genome and plays a crucial role in almost every …

Genetically incorporating two distinct post-translational modifications into one protein simultaneously

S Venkat, J Sturges, A Stahman, C Gregory… - ACS synthetic …, 2018 - ACS Publications
Post-translational modifications (PTMs) play important roles in regulating a variety of
biological processes. To facilitate PTM studies, the genetic code expansion strategy has …

[HTML][HTML] Deciphering post-translational modification codes

AP Lothrop, MP Torres, SM Fuchs - FEBS letters, 2013 - Elsevier
Post-translational modifications (PTMs) occur on nearly all proteins. Many domains within
proteins are modified on multiple amino acid sidechains by diverse enzymes to create a …

Posttranslational chemical mutagenesis methods to insert posttranslational modifications into recombinant proteins

O Harel, M Jbara - Molecules, 2022 - mdpi.com
Posttranslational modifications (PTMs) dramatically expand the functional diversity of the
proteome. The precise addition and removal of PTMs appears to modulate protein structure …

Applications of genetic code expansion in studying protein post-translational modification

J Chen, YH Tsai - Journal of Molecular Biology, 2022 - Elsevier
Various post-translational modifications can naturally occur on proteins, regulating the
activity, subcellular localization, interaction, or stability of the proteins. However, it can be …

dbPTM in 2022: an updated database for exploring regulatory networks and functional associations of protein post-translational modifications

Z Li, S Li, M Luo, JH Jhong, W Li, L Yao… - Nucleic acids …, 2022 - academic.oup.com
Protein post-translational modifications (PTMs) play an important role in different cellular
processes. In view of the importance of PTMs in cellular functions and the massive data …