LPS-induced murine neuroinflammation model: main features and suitability for pre-clinical assessment of nutraceuticals

M Nava Catorce, G Gevorkian - Current neuropharmacology, 2016 - ingentaconnect.com
Neuroinflammation is an important feature in the pathogenesis and progression of
neurodegenerative diseases such as Alzheimer´ s disease (AD), Parkinson´ s disease (PD) …

Lipopolysaccharide-induced model of neuroinflammation: mechanisms of action, research application and future directions for its use

A Skrzypczak-Wiercioch, K Sałat - Molecules, 2022 - mdpi.com
Despite advances in antimicrobial and anti-inflammatory therapies, inflammation and its
consequences still remain a significant problem in medicine. Acute inflammatory responses …

Role of neuroinflammation in neurodegeneration development

W Zhang, D Xiao, Q Mao, H Xia - Signal transduction and targeted …, 2023 - nature.com
Studies in neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease
and Amyotrophic lateral sclerosis, Huntington's disease, and so on, have suggested that …

Lipopolysaccharide-induced neuroinflammation as a bridge to understand neurodegeneration

CRA Batista, GF Gomes, E Candelario-Jalil… - International journal of …, 2019 - mdpi.com
A large body of experimental evidence suggests that neuroinflammation is a key
pathological event triggering and perpetuating the neurodegenerative process associated …

Dietary protection against cognitive impairment, Neuroinflammation and oxidative stress in Alzheimer's disease animal models of lipopolysaccharide-induced …

D Decandia, F Gelfo, E Landolfo, F Balsamo… - International Journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is a rapidly growing epidemic with a heavy social and economic
burden. Evidence suggests that systemic inflammation, dysregulation of the immune …

Systemic LPS administration induces brain inflammation but not dopaminergic neuronal death in the substantia nigra

HK Jeong, I Jou, E Joe - Experimental & molecular medicine, 2010 - nature.com
It has been suggested that brain inflammation is important in aggravation of brain damage
and/or that inflammation causes neurodegenerative diseases including Parkinson's disease …

Sterile neuroinflammation and strategies for therapeutic intervention

M Banjara, C Ghosh - International journal of inflammation, 2017 - Wiley Online Library
Sterile neuroinflammation is essential for the proper brain development and tissue repair.
However, uncontrolled neuroinflammation plays a major role in the pathogenesis of various …

Neuroinflammation in neurological disorders: pharmacotherapeutic targets from bench to bedside

A Mishra, R Bandopadhyay, PK Singh, PS Mishra… - Metabolic Brain …, 2021 - Springer
Neuroinflammation is one of the host defensive mechanisms through which the nervous
system protects itself from pathogenic and or infectious insults. Moreover, neuroinflammation …

Neuroinflammation mechanisms and phytotherapeutic intervention: A systematic review

N Kaur, H Chugh, MK Sakharkar… - ACS chemical …, 2020 - ACS Publications
Neuroinflammation is indicated in the pathogenesis of several acute and chronic
neurological disorders. Acute lesions in the brain parenchyma induce intense and highly …

Protective effect of lupeol against lipopolysaccharide-induced neuroinflammation via the p38/c-Jun N-terminal kinase pathway in the adult mouse brain

H Badshah, T Ali, S Rehman, F Amin, F Ullah… - Journal of Neuroimmune …, 2016 - Springer
Recent studies have demonstrated a close interaction between neuroinflammatory
responses, increased production of inflammatory mediators, and neurodegeneration …