Characteristics of gut microbiota and metabolic phenotype in patients with major depressive disorder based on multi-omics analysis

X Zu, J Xin, H Xie, X Xu, Y Shen, J Wang, S Tian… - Journal of Affective …, 2024 - Elsevier
Depression is a chronic, relapsing mental illness, often accompanied by loss of appetite,
increased fatigue, insomnia and poor concentration. Here, we performed serum and urine …

Changes of gut microbiota reflect the severity of major depressive disorder: a cross sectional study

X Hu, Y Li, J Wu, H Zhang, Y Huang, X Tan… - Translational …, 2023 - nature.com
Disturbed gut microbiota is a potential factor in the pathogenesis of major depressive
disorder (MDD), yet whether gut microbiota dysbiosis is associated with the severity of MDD …

Gut microbiome composition linked to inflammatory factors and cognitive functions in first-episode, drug-naive major depressive disorder patients

P Liu, M Gao, Z Liu, Y Zhang, H Tu, L Lei… - Frontiers in …, 2022 - frontiersin.org
Objective The microbiota–gut–brain axis, especially the inflammatory pathway, may play a
critical role in the pathogenesis of cognitive impairment in major depressive disorder (MDD) …

Comparative metaproteomics analysis shows altered fecal microbiota signatures in patients with major depressive disorder

Z Chen, J Li, S Gui, C Zhou, J Chen, C Yang, Z Hu… - …, 2018 - journals.lww.com
Major depressive disorder (MDD) is a highly prevalent and debilitating mental illness, which
is associated with disorder of gut microbiota. However, few studies focusing on detection of …

Gut microbiota variations in patients diagnosed with major depressive disorder—A systematic review

JK Knudsen, C Bundgaard‐Nielsen… - Brain and …, 2021 - Wiley Online Library
Objective The etiology of major depressive disorder (MDD) is multi‐factorial and has been
associated with a perturbed gut microbiota. Thus, it is therefore of great importance to …

[HTML][HTML] Integrated multi-omics analysis reveals gut microbiota dysbiosis and systemic disturbance in major depressive disorder

Z Xie, J Huang, G Sun, S He, Z Luo, L Zhang, L Li… - Psychiatry …, 2024 - Elsevier
Major depressive disorder (MDD) involves systemic changes in peripheral blood and gut
microbiota, but the current understanding is incomplete. Herein, we conducted a multi-omics …

A pilot exploration of multi-omics research of gut microbiome in major depressive disorders

H Zhao, K Jin, C Jiang, F Pan, J Wu, H Luan… - Translational …, 2022 - nature.com
The pathophysiology of major depressive disorder (MDD) remains obscure. Recently, the
microbiota-gut-brain (MGB) axis's role in MDD has an increasing attention. However, the …

Differential gut microbiota compositions related with the severity of major depressive disorder

Q Zhong, J Chen, Y Wang, W Shao, C Zhou… - Frontiers in Cellular and …, 2022 - frontiersin.org
Objective Increasing evidence shows a close relationship between gut microbiota and major
depressive disorder (MDD), but the specific mechanisms remain unknown. This study was …

Proteomics analysis of the gut–brain axis in a gut microbiota-dysbiosis model of depression

Y Liu, H Wang, S Gui, B Zeng, J Pu, P Zheng… - Translational …, 2021 - nature.com
Major depressive disorder (MDD) is a serious mental illness. Increasing evidence from both
animal and human studies suggested that the gut microbiota might be involved in the onset …

Gut microbiota dysbiosis in depressed women: The association of symptom severity and microbiota function

Y Chen, F Xue, S Yu, X Li, L Liu, Y Jia, W Yan… - Journal of Affective …, 2021 - Elsevier
Background The association between abnormal gut microbiome composition and
depression is well established. However, the composition and functional capacity of the gut …