Ameloblastin attenuates RANKL‐mediated osteoclastogenesis by suppressing activation of nuclear factor of activated T‐cell cytoplasmic 1 (NFATc1)

W Chaweewannakorn, W Ariyoshi… - Journal of Cellular …, 2019 - Wiley Online Library
Ameloblastin (Ambn) is an extracellular matrix protein and member of the family of enamel‐
related gene products. Like amelogenin, Ambn is mainly associated with tooth development …

Ameloblastin and enamelin prevent osteoclast formation by suppressing RANKL expression via MAPK signaling pathway

W Chaweewannakorn, W Ariyoshi, T Okinaga… - Biochemical and …, 2017 - Elsevier
Abstract Ameloblastin (Ambn) and enamelin (Enam) play a pivotal role in enamel
mineralization. Previous studies have demonstrated that these enamel-related gene …

Ameloblastin modulates osteoclastogenesis through the integrin/ERK pathway

X Lu, Y Ito, P Atsawasuwan, S Dangaria, X Yan, T Wu… - Bone, 2013 - Elsevier
Proteins of the extracellular matrix often have multiple functions to facilitate complex tasks
ranging from signaling to structural support. Here we have focused on the function of one of …

Ameloblastin, an extracellular matrix protein, affects long bone growth and mineralization

X Lu, S Fukumoto, Y Yamada, CA Evans… - Journal of Bone and …, 2016 - academic.oup.com
Matrix molecules such as the enamel‐related calcium‐binding phosphoprotein ameloblastin
(AMBN) are expressed in multiple tissues, including teeth, bones, and cartilage. Here we …

[HTML][HTML] The receptor activator of nuclear factor-κB ligand-mediated osteoclastogenic pathway is elevated in amelogenin-null mice

J Hatakeyama, T Sreenath, Y Hatakeyama… - Journal of Biological …, 2003 - ASBMB
Amelogenins, major components of developing enamel, are predominantly involved in the
formation of tooth enamel. Although amelogenins are also implicated in cementogenesis …

Ameloblastin promotes bone growth by enhancing proliferation of progenitor cells and by stimulating immunoregulators

MV Tamburstuen, S Reppe, A Spahr… - European journal of …, 2010 - Wiley Online Library
Tamburstuen MV, Reppe S, Spahr A, Sabetrasekh R, Kvalheim G, Slaby I, Syversen U,
Lyngstadaas SP, Reseland JE. Ameloblastin promotes bone growth by enhancing …

[PDF][PDF] Ameloblastin is not implicated in bone remodelling and repair

S Kuroda, R Wazen, K Sellin, E Tanaka, P Moffatt… - Eur Cell …, 2011 - ecmjournal.org
Ameloblastin (AMBN) is an enamel matrix protein produced by ameloblasts. It has been
suggested that AMBN might also be implicated in craniofacial bone formation. Our objective …

[HTML][HTML] Arctigenin inhibits osteoclast differentiation and function by suppressing both calcineurin-dependent and osteoblastic cell-dependent NFATc1 pathways

T Yamashita, S Uehara, N Udagawa, F Li, S Kadota… - PLoS …, 2014 - journals.plos.org
Arctigenin, a lignan-derived compound, is a constituent of the seeds of Arctium lappa.
Arctigenin was previously shown to inhibit osteoclastogenesis; however, this inhibitory …

Punicalagin attenuates osteoclast differentiation by impairing NFATc1 expression and blocking Akt-and JNK-dependent pathways

M Iwatake, K Okamoto, T Tanaka, T Tsukuba - Molecular and cellular …, 2015 - Springer
Punicalagin is a bioactive polyphenol that is classified as an ellagitannin. Although
punicalagin has been shown to have various pharmacological effects, such as anti …

L-type Ca2+ channel agonist inhibits RANKL-induced osteoclast formation via NFATc1 down-regulation

ALSM Noh, H Park, T Zheng, HI Ha, M Yim - Life sciences, 2011 - Elsevier
AIMS: BayK 8644 is an L-type Ca2+ channel agonist that enhances Ca2+ influx and
elevates cytosolic Ca2+. As intracellular calcium plays a key role in osteoclast formation, we …