Ameloblastin attenuates RANKL‐mediated osteoclastogenesis by suppressing activation of nuclear factor of activated T‐cell cytoplasmic 1 (NFATc1)
W Chaweewannakorn, W Ariyoshi… - Journal of Cellular …, 2019 - Wiley Online Library
Ameloblastin (Ambn) is an extracellular matrix protein and member of the family of enamel‐
related gene products. Like amelogenin, Ambn is mainly associated with tooth development …
related gene products. Like amelogenin, Ambn is mainly associated with tooth development …
Ameloblastin and enamelin prevent osteoclast formation by suppressing RANKL expression via MAPK signaling pathway
W Chaweewannakorn, W Ariyoshi, T Okinaga… - Biochemical and …, 2017 - Elsevier
Abstract Ameloblastin (Ambn) and enamelin (Enam) play a pivotal role in enamel
mineralization. Previous studies have demonstrated that these enamel-related gene …
mineralization. Previous studies have demonstrated that these enamel-related gene …
Ameloblastin modulates osteoclastogenesis through the integrin/ERK pathway
X Lu, Y Ito, P Atsawasuwan, S Dangaria, X Yan, T Wu… - Bone, 2013 - Elsevier
Proteins of the extracellular matrix often have multiple functions to facilitate complex tasks
ranging from signaling to structural support. Here we have focused on the function of one of …
ranging from signaling to structural support. Here we have focused on the function of one of …
Ameloblastin, an extracellular matrix protein, affects long bone growth and mineralization
X Lu, S Fukumoto, Y Yamada, CA Evans… - Journal of Bone and …, 2016 - academic.oup.com
Matrix molecules such as the enamel‐related calcium‐binding phosphoprotein ameloblastin
(AMBN) are expressed in multiple tissues, including teeth, bones, and cartilage. Here we …
(AMBN) are expressed in multiple tissues, including teeth, bones, and cartilage. Here we …
[HTML][HTML] The receptor activator of nuclear factor-κB ligand-mediated osteoclastogenic pathway is elevated in amelogenin-null mice
J Hatakeyama, T Sreenath, Y Hatakeyama… - Journal of Biological …, 2003 - ASBMB
Amelogenins, major components of developing enamel, are predominantly involved in the
formation of tooth enamel. Although amelogenins are also implicated in cementogenesis …
formation of tooth enamel. Although amelogenins are also implicated in cementogenesis …
Ameloblastin promotes bone growth by enhancing proliferation of progenitor cells and by stimulating immunoregulators
MV Tamburstuen, S Reppe, A Spahr… - European journal of …, 2010 - Wiley Online Library
Tamburstuen MV, Reppe S, Spahr A, Sabetrasekh R, Kvalheim G, Slaby I, Syversen U,
Lyngstadaas SP, Reseland JE. Ameloblastin promotes bone growth by enhancing …
Lyngstadaas SP, Reseland JE. Ameloblastin promotes bone growth by enhancing …
[PDF][PDF] Ameloblastin is not implicated in bone remodelling and repair
Ameloblastin (AMBN) is an enamel matrix protein produced by ameloblasts. It has been
suggested that AMBN might also be implicated in craniofacial bone formation. Our objective …
suggested that AMBN might also be implicated in craniofacial bone formation. Our objective …
[HTML][HTML] Arctigenin inhibits osteoclast differentiation and function by suppressing both calcineurin-dependent and osteoblastic cell-dependent NFATc1 pathways
T Yamashita, S Uehara, N Udagawa, F Li, S Kadota… - PLoS …, 2014 - journals.plos.org
Arctigenin, a lignan-derived compound, is a constituent of the seeds of Arctium lappa.
Arctigenin was previously shown to inhibit osteoclastogenesis; however, this inhibitory …
Arctigenin was previously shown to inhibit osteoclastogenesis; however, this inhibitory …
Punicalagin attenuates osteoclast differentiation by impairing NFATc1 expression and blocking Akt-and JNK-dependent pathways
M Iwatake, K Okamoto, T Tanaka, T Tsukuba - Molecular and cellular …, 2015 - Springer
Punicalagin is a bioactive polyphenol that is classified as an ellagitannin. Although
punicalagin has been shown to have various pharmacological effects, such as anti …
punicalagin has been shown to have various pharmacological effects, such as anti …
L-type Ca2+ channel agonist inhibits RANKL-induced osteoclast formation via NFATc1 down-regulation
ALSM Noh, H Park, T Zheng, HI Ha, M Yim - Life sciences, 2011 - Elsevier
AIMS: BayK 8644 is an L-type Ca2+ channel agonist that enhances Ca2+ influx and
elevates cytosolic Ca2+. As intracellular calcium plays a key role in osteoclast formation, we …
elevates cytosolic Ca2+. As intracellular calcium plays a key role in osteoclast formation, we …