Purpose: CDK-activating kinase (CAK) is required for the regulation of the cell cycle and is a
trimeric complex consisting of cyclin-dependent kinase 7 (CDK7), Cyclin H, and the …

Abstract Cyclin-dependent kinase 7 (CDK7), along with cyclin H and MAT1, forms the CDK-
activating complex (CAK), which directs progression through the cell cycle via T-loop …

CDK7 has been known as a component of CDK activating kinase (CAK) complex, the
complex was composed of CDK7, Cyclin H and RING finger protein Mat1 that contribute to …

Background Cyclin-dependent kinase 10 (CDK10) has recently been identified as a tumor
suppressor and, concordantly, its encoding gene has frequently been found to be …

The Cyclin-dependent kinase (CDK) Activating Kinase (CAK) is responsible for the
activating phosphorylation of CDK1, CDK2, CDK4 and CDK6 and regulation of the cell …

The regulation and function of cyclin‐dependent kinase 6 (CDK6)‐and cyclin‐dependent
kinase 4 (CDK4)‐cyclin complexes are commonly altered with enhanced kinase activity …

Cyclin-dependent kinases (CDKs) play important roles in the development of many types of
cancers by binding with their paired cyclins. However, the function of CDK11 larger protein …

Abstract Cyclin-dependent kinase 7 (CDK7) serves as a pivotal regulator in orchestrating
cellular cycle dynamics and gene transcriptional activity. Elevated expression levels of …

Cyclin-dependent kinases (CDKs) play critical roles in cell cycle progression and gene
expression regulation. In human cancer, transcription-associated CDKs can activate …

Cyclin-dependent kinases (CDKs) are a group of serine/threonine protein kinases and play
crucial roles in various cellular processes by regulating cell cycle and gene transcription …