The transition from acute to chronic pain is critically important but not well understood. Here,
we investigated the pathophysiological mechanisms underlying the transition from acute to …

Chronic pain is a refractory health disease worldwide causing an enormous economic
burden on individuals and society. Accumulating evidence suggests that inflammation in the …

Chronic pain is a debilitating and poorly treated condition whose underlying mechanisms
are poorly understood. Nerve injury and inflammation cause alterations in gene expression …

Bidirectional interactions between the immune system and the nervous system are
increasingly appreciated as playing a pathogenic role in chronic pain. Unraveling the …

Current pain therapeutics offer inadequate relief to patients with chronic pain. A growing
literature supports that pro-inflammatory cytokine signaling between immune, glial, and …

Dysregulation of the immune system may play a role in chronic pain, although study findings
are inconsistent. This cross-sectional study examined whether basal inflammatory markers …

Neuropathic pain is a complex chronic condition characterized by various sensory,
cognitive, and affective symptoms. A large percentage of patients with neuropathic pain are …

Low-grade systemic inflammation has been implicated in chronic pain, as well as in
comorbid diseases like depression and fatigue. We have previously shown that women's …

Chronic pain is a substantial personal and societal burden worldwide. Osteoarthritis (OA) is
one of the leading causes of chronic pain and is increasing in prevalence in accordance …

Chronic neuropathic pain is a major morbidity of neural injury, yet its mechanisms are
incompletely understood. Hypersensitivity to previously non-noxious stimuli (allodynia) is a …